托吡酯联合拉莫三嗪对癫痫患者认知功能和生活质量的影响

目的:探讨托吡酯联合拉莫三嗪对癫痫患者认知功能和生活质量的影响。方法:选择2016年1月到2018年2月我院诊治的癫痫患者60例进行回顾性分析,根据治疗方法不同分为两组,各30例,对照组给予托吡酯治疗,观察组在对照组治疗的基础上给予拉莫三嗪治疗。两组均治疗观察3个疗程,记录和比较其认知功能和生活质量变化情况以及不良反应发生情况。结果:治疗后,观察组的总有效率显著高于对照组(96.6%vs.73.3%,P<0.05)。两组治疗期间的胃肠道反应、神经系统反应、精神症状、全身反应等不良反应情况对比差异无统计学意义(P>0.05)。两组治疗后的蒙特利尔认知评估量表(Montreal Cognitive Assessment,Mo CA)评分均显著高于治疗前(P<0.05),且观察组显著高于对照组(P<0.05)。此外,观察组治疗后的生活满意度、生活打扰、积极影响、身体健康、心理应对等生活质量评分均显著高于对照组(P<0.05)。结论:托吡酯联合拉莫三嗪用于治疗癫痫患者能显著改善认知功能,提高患者生活质量与治疗效果,且安全性较高。

Effects of Topiramate Combined with Lamotrigine on Cognitive Function and Quality of Life in Patients with Epilepsy

ABSTRACT Objective: To investigate the effects of topiramate combined with lamotrigine on cognitive function and quality of life in patients with epilepsy. Methods: Sixty patients with epilepsy who were treated in our hospital from January 2016 to February 2018 were retrospectively analyzed. According to different treatment methods, they are divided into two groups, 30 cases each. The control group were treated with topiramate, the observation group were given with lamotrigine on the basis of the control group. The two groups were treated for 3 courses, the changes in cognitive function, quality of life and the incidence of adverse reactions were recorded and compared. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group (96.6% vs. 73.3%, P<0.05). There were no significant differences in adverse reactions of gastrointestinal reactions, nervous system reactions, psychotic symptoms and systemic reactions comapred betweeen the two gorups during the treatment(P>0.05). The MoCA scores of the two groups were significantly higher than those before treatment(P<0.05), and the observation group were significantly higher than the control group(P<0.05). In addition, the quality of life scores of life observation, life interruption, positive influence, physical health, and psychological coping were significantly higher in the observation group than in the control group(P<0.05). Conclusion: Topiramate combined with lamotrigine for the treatment patients with epilepsy can significantly improve cognitive function, improve patients'' quality of life and treatment, and have higher safety.