定坤丹联合复宫宁颗粒治疗子宫内膜异位症的疗效及对血清MCP-1、sICAM-1、CA125水平的影响

目的:探讨定坤丹联合复宫宁颗粒治疗子宫内膜异位症的疗效及对血清单核细胞趋化蛋白-1(MCP-1)、可溶性细胞间粘附分子(s ICAM-1)、CA125水平的影响。方法:选择2014年12月至2016年12月我院接诊的96例子宫内膜异位症患者,通过随机数表法将其分为观察组(n=48)和对照组(n=48)。对照组给予醋酸亮丙瑞林微球注射液联合定坤丹治疗,观察组在对照组基础上联合复宫宁颗粒治疗,两组均连续治疗3个疗程。比较两组治疗前后卵泡生成激素(FSH)、黄体生成激素(LH)、雌二醇(E2)及血清MCP-1、s ICAM-1、CA125水平的变化,临床疗效及不良反应的发生情况。结果:治疗后,观察组临床疗效总有效率明显高于对照组(93.75%vs.70.83%,P<0.05),FSH、LH明显低于对照组,E2明显高于对照组(P<0.05);两组血清MCP-1、s ICAM-1、CA125较治疗前均显著降低(P<0.05),观察组以上指标明显低于对照组(P<0.05)。此外,观察组潮热、多汗、阴道出血总发生率明显低于对照组(P<0.05)。结论:与醋酸亮丙瑞林微球注射液联合定坤丹治疗相比,定坤丹联合复宫宁颗粒治疗子宫内膜异位症的效果更好,其可有效改善患者卵巢内分泌功能,缓解临床症状,其内在机制可能和降低血清MCP-1、s ICAM-1、CA125水平相关。

Efficacy of Dingkundan Combined with Fugongning Granule in the Treatment of Endometriosis and Its Effects on the Serum MCP-1, sICAM-1 and CA125 Levels

Objective:To study the efficacy of Dingkundan combined with fugongning granule in the treatment of endometriosis and its effects on the serum monocyte chemotactic protein-1(MCP-1),soluble intercellular adhesion molecule(sICAM-1)and CA125 levels.Methods:96 patients of endometriosis who were treated in our hospital from December 2014 to December 2016 were selected.According to the random number table,those patients were divided into the observation group(n=48)and the control group(n=48).The control group was treated with leuprorelin acetate microsphere injection combined with Dingkundan,the observation group was treated by fugongning granule on the basis of control group,both groups were continuously treated for 3 courses.The changes of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),serum MCP-1,sICAM-1,CA125 levels before and after treatment,the clinical efficacy and the incidence of adverse reactions were compared between two groups.Results:After treatment,the total effective rate of observation group was higher than that of the control group(93.75%vs.70.83%P<0.05);the FSH and LH were significantly lower than those of the control group,and the E2 was significantly higher than that of the control group(P<0.05);the serum MCP-1,sICAM-1 and CA125 levels were significantly lower in the observation group than that of the control group(P<0.05).In addition,the total incidence of hot flashes,hyperhidrosis and vaginal bleeding in the observation group was significantly lower than that of the control group(P<0.05).Conclusion:Compared with leuprorelin acetate microsphere injection combined with Dingkundan,Dingkundan combined with fugongning granule is more effective in treating endometriosis,which can effectively improve the ovarian endocrine function and alleviate clinical symptoms,it’s intrinsic mechanism may be related to the decrease of serum MCP-1,sICAM-1 and CA125 levels.