自身免疫性溶血性贫血(AIHA)患者的不同输血方法与效果

目的:探讨不同输血方法治疗自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)的效果。方法:2017年1月-2018年12月选择在本院血液科诊治的64例自身免疫性溶血性贫血患儿,根据输血方法的不同分为观察组与对照组,各32例。观察组给予洗涤红细胞输注治疗,对照组给予非洗涤红细胞(悬浮红细胞)输注治疗,记录两组输血效果。结果:治疗后4 w观察组的总有效率显著高于对照组(100.0%vs.87.5%,P0.05)。两组治疗后4 w的红细胞计数与血红蛋白都显著高于治疗前,且观察组显著高于对照组(P0.05)。观察组的吸氧、机械通气、住院时间都显著少于对照组(P0.05)。观察组治疗过程的过敏反应、发热反应、紫癜等不良反应发生率显著低于对照组(3.1%vs. 21.9%,P0.05)。结论:洗涤红细胞输注治疗自身免疫性溶血性贫血患儿能促进机体红细胞计数与血红蛋白恢复正常,减少不良反应的发生,提高治疗效果与促进患儿康复。

Different Transfusion Methods and Effects in Patients with Autoimmune Hemolytic Anemia (AIHA)

ABSTRACT Objective: To explore the effects of different blood transfusion methods on autoimmune hemolytic anemia (AIHA). Methods: 64 cases of children with autoimmune hemolytic anemia diagnosed and treated in the hematology department from January 2017 to December 2018 of our hospital were selected as the research subjects and were divided into observation group and control group with 32 cases in each groups accorded to the different blood transfusion methods. The observation group were given washed erythrocyte infusion treatment, and the control group were given non-wash erythrocyte (suspended red blood cell) infusion treatment, and the transfusion effects were recorded in the both groups. Results: 4 weeks post-treatment, the total effective rate in the observation group was significantly higher than that in the control group (100.0% vs. 87.5%, P<0.05). The red blood cell count and hemoglobin at 4 weeks post-treatment in two groups were significantly higher than pretherapy, and the observation group was significantly higher than the control group (P<0.05). The oxygen intake, mechanical ventilation, and hospital stay of the observation group were significantly shorter than those of the control group (P<0.05). The incidence of allergic reactions, fever reactions, and purpura in the observation group was significantly lower than that in the control group (3.1 % vs. 21.9 %, P<0.05). Conclusion: The washing red blood cell infusion for children with autoimmune hemolytic anemia can promote the body''s red blood cell count and hemoglobin to return to normal, reduce the occurrence of adverse reactions, improve the treatment effect and promote the rehabilitation of children.