氯雷他定对急性支气管炎患儿免疫功能及炎症反应的影响

目的:分析氯雷他定对急性支气管炎患儿免疫功能及炎症反应的影响。方法:收集我院收治的急性支气管炎患儿100例,将其随机分为对照组与观察组,每组50例。对照组患儿给予常规治疗;观察组患儿给予常规治疗联合氯雷他定治疗。比较两组患儿治疗前后动脉氧分压(PaO_2)、二氧化碳分压(PaCO_2)、CD3~+、CD4~+、CD4~+/CD8~+、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、血清降钙素原(PCT)、C反应蛋白(CRP)及白介素-6(IL-6)水平的变化。结果:治疗后,观察组患儿PaO_2水平明显高于对照组,PaCO_2水平明显低于对照组(P0.05);两组患儿细胞免疫及体液免疫水平较治疗前比较均显著升高(P0.05),且观察组患儿CD3~+、CD4~+、CD4~+/CD8~+、IgA、IgG及IgM水平明显高于对照组患儿(P0.05)。治疗后,两组患儿血清中PCT、CRP及IL-6水平均较治疗前显著降低,且观察组患儿上述炎症因子水平明显低于对照组患儿(P0.05)。结论:氯雷他定治疗小儿急性支气管炎可显著提高患儿的免疫功能,抑制炎症因子释放,缓解炎症反应,临床效果显著。

Effect of Loratadine on the Immune Function and Inflammatory Response in Children with Acute Bronchitis

ABSTRACT Objective: To analyze the effect of loratadine on the immune function and inflammatory response in children with acute bronchitis. Methods: 100 cases of children with acute bronchitis in our hospital were randomly divided into the control group and the observation group with 50 cases in each group. The children in the control group were treated with conventional therapy, while the children in the observation group were treated with conventional therapy combined with loratadine. The levels of partial pressure of arterial oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂), CD3⁺, CD4⁺, CD4⁺/CD8⁺, immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) were compared between the two groups before and after treatment. Results: After treatment, the levels of PaO₂ of patients in the observation group were significantly higher than those in the control group, and the levels of PaCO₂ were significantly lower than those in the control group (P<0.05). The levels of cellular immunity and humoral immunity of patients in the two groups were significantly higher than those before treatment (P<0.05), and the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺, IgA, IgG and IgM of patients in the observation group were significantly higher than those in the control group (P<0.05). After treatment, the levels of PCT, CRP and IL-6 in serum of patients in the two groups were significantly lower than those before treatment, and the above inflammatory factors of patients in the observation group were significantly lower than those in the control group (P<0.05). Conclusion: Loratadine combined with azithromycin can significantly improve the immune function of children, inhibit the release of inflammatory factors in the treatment of children with acute bronchitis.