保肺膏维持治疗晚期非小细胞肺癌临床观察

目的:观察保肺膏维持治疗晚期非小细胞肺癌的临床疗效。方法:选自2017年10月至2018年10月在辽宁省肿瘤医院、辽宁中医药大学附属医院、辽宁中医药大学附属二院、沈阳市第二中医院四家医院住院的48例Ⅲ-Ⅳ期非小细胞肺癌(Non-small cell lung cancer, NSCLC)带瘤患者为研究对象,根据随机数字表法,将患者分治疗组和对照组,各24例,观察和记录两组患者肿瘤无进展生存期(Progression-free survival,PFS)、评估治疗前后的生活质量、治疗后中医症状和卡氏评分(Karnofsky performance status,KPS)改善情况。结果:治疗后,治疗组的中位PFS为(6.00±0.76)个月,对照组的中位PFS为(4.00±0.81)个月。治疗前,两组的生活质量情况各领域对比后均无统计学差异(P0.05)。治疗后,两组的生活质量情况均优于治疗前(P0.05),功能领域中的躯体功能、角色功能、情绪功能评分均显著高于治疗前(P0.05),在症状领域中疲劳、疼痛、恶心呕吐评分均显著低于治疗前(P0.05),在单一症状领域中,失眠、便秘、纳差、呼吸困难评分均低于治疗前(P0.05),腹泻评分、经济困难评分无显著性差异(P0.05),患者的整体健康状况评分显著高于治疗前(P0.05)。治疗后,治疗组在躯体功能、角色功能和情绪功能、症状领域和失眠、便秘、纳差和呼吸困难和总体健康状况的评分情况均明显优于对照组(P0.05)。治疗后,治疗组中医症状疗效总有效率为20(83.33%),显著高于对照组的12(50.00%)(P0.05)。治疗后,治疗组KPS评分总改善率为22(91.67%),显著高于对照组的15(62.50%)(P0.05)。结论:"保肺膏"能够起到延长生存期,提高生活质量的作用,改善中医症状和KPS评分,可以作为晚期NSCLC"带瘤生存"维持治疗的选择用药,值得临床推广应用。

Clinical Observation of Baofei Ointment Maintenance Therapy for Advanced Non-small Cell Lung Cancer

ABSTRACT Objective: To observe the clinical efficacy of Baofei Ointment in the maintenance of treatment advanced non-small cell lung cancer. Methods: 48 patients with stage III-IV Non-small cell lung cancer (NSCLC) tumors were selected as subjects in Liaoning cancer hospital & institute, the Affiliated Hospital of Liaoning Hospital of Traditional Chinese Medicine (TCM), the second affiliated hospital of Liaoning Hospital of TCM and the second Hospital of Shenyang TCM From October 2017 to October 2018. According to random number table method, the patients were divided into treatment group and control group, 24 cases in each group. Progression-free survival (PFS), quality of life before and after treatment, post-treatment TCM symptoms and Karnofsky performance status (KPS) improvement were observed and calculated. Results: After treatment, the median PFS of the treatment group was (6.00±0.76) months, and that of the control group was (4.00±0.81) months. Before treatment, there was no significant difference in the quality of life between the two groups (P>0.05). After treatment, the quality of life of the two groups was better than that before treatment (P<0.05). The scores of physical function, role function and emotional function in the functional area were higher than those before treatment(P<0.05). The scores of fatigue, pain, nausea and vomiting in the symptom area were lower than those before treatment(P<0.05). The scores of insomnia, constipation, anorexia and dyspnea were lower than those before treatment in the area of single symptom(P<0.05). There was no significant difference in diarrhea score and financial difficulties score(P>0.05). The general health score of patients was significantly higher than that before treatment(P<0.05). After treatment, the scores of physical function, role function and emotional function, symptoms areas, insomnia, constipation, anorexia, dyspnea and general health status in the treatment group were significantly better than those in the control group(P<0.05). After treatment, the total effective rate of TCM symptoms in the treatment group was 20(83.33%), which was significantly higher than that in the control group 12(50.00%)(P<0.05). After treatment, the total improvement rate of KPS score in the treatment group was 22(91.67%), which was significantly higher than that in the control group 15 (62.50%) (P<0.05). Conclusion: Baofei Ointment can prolong the survival time, improve the quality of life, improve the symptoms of TCM and KPS score. It can be used as an alternative drug for the maintenance treatment of advanced NSCLC with tumor, and is worthy of clinical application.