553 例女性宫颈高危型HPV 感染与宫颈病变的相关性研究

目的:研究女性生殖道高危型人乳头瘤病毒(high risk human papilloma virus,hrHPV)感染现状及子宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CI N)的现患率,并分析该人群年龄与HPV感染及宫颈癌前病变的相关性以及hrHPV病毒载量与宫颈病变之间剂量-效应关系。方法:对553例30岁-78岁有性生活史的女性进行以人群为基础的横断面调查。对所有接受筛查的妇女均行宫颈HPV检测及电子阴道镜下病理活检,并以病理结果作为诊断子宫颈病变的金标准。资料采用EXCEL整理,利用x2检验和非条件Logistic回归分析危险因素和CI N的关系。结果:553例受检对象总体阳性检出率为18.0%。hrHPV感染情况在不同年龄段分布有显著差异,hrHPV病毒载量越高宫颈病变的程度越重。结论:不同年龄段hrHPV感染情况不同,hrHPV病毒载量与宫颈病变之间存在剂量-效应关系。

Correlation of Cervical Lesions and Cervical High-risk HPV Infection in 553 Women

Objective: To study the prevalence rate of female genital tract high risk human papill oma virus (hrHPV) infection and cervical intraepithelial neoplasia (cervical intraepithelial neoplasia, CIN), to analysis the HPV infection condition in different age group, to analysis the relationship between cervical lesions and viral load of hrHPV. Methods: A total of 553 women aged 30-78 years old received population-based cross-sectional survey. All women received HPV detection and cervical biopsy under colposcopy, and pathology results as the gold standard for diagnosis of cervical lesions. Sorting data using EXCEL, usingx2 test and unconditional Logistic regression analysis of risk factors and the relationship between CIN. Results: The overall positive hrHPV detection rate of 553 women is 18.0%, hrHPV infection in different age distributions were significantly different, the higher the hrHPV viral load, the worser the cervical lesions. Conclusion: hrHPV infection in different age groups with different distribution, there is closely correlation between hrHPV viral load and cervical lesions.