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MPTP/MPP+ 诱导神经元凋亡的机制研究
引用本文:张玉花,蔡蕊,刘江华,朱春雨,解洪荣.MPTP/MPP+ 诱导神经元凋亡的机制研究[J].现代生物医学进展,2011,11(5):964-967.
作者姓名:张玉花  蔡蕊  刘江华  朱春雨  解洪荣
作者单位:1. 大庆油田总医院CT室,黑龙江,大庆,163001
2. 天津南开华山医院,天津,300000
3. 大庆油田总医院神经内科,黑龙江,大庆,163001
摘    要:1982年人们发现1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)能诱发PD,它的有效成分是1-甲基-4-苯基吡啶离子(MPP+)。目前,MPTP/MPP+广泛的被用作诱导PD实验模型的有效药物,可诱导神经元细胞发生凋亡性死亡。MPTP/MPP+诱导细胞凋亡的机制牵涉Bcl-2、p53、caspase家族、JNK通路、ERK通路和PARP等多种机制,它们共同参与了MPTP/MPP+诱导的细胞凋亡的调控和执行阶段。本文主要综述MPTP/MPP+诱导的神经元细胞凋亡机制。

关 键 词:1-甲基-4-苯基-1  2  3  6-四氢吡啶(MPTP)  1-甲基-4-苯基吡啶离子(MPP+)  帕金森病(PD)  凋亡

The study of MPTP/MPP+-induced apoptosis of neurons
ZHANG Yu-hu,CAI Rui,LIU Jiang-hu,ZHU Chun-yun,XIE Hong-rong.The study of MPTP/MPP+-induced apoptosis of neurons[J].Progress in Modern Biomedicine,2011,11(5):964-967.
Authors:ZHANG Yu-hu  CAI Rui  LIU Jiang-hu  ZHU Chun-yun  XIE Hong-rong
Institution:1 Department of Computerized Tomography,Daqing Oilfield General Hospital,Heilongjiang,Daqing 163001,China 2 Tianjin nankai huashan hospital,Tianjin city,300000,China;3 Department of Neurology,Daqing Oilfield General Hospital,Heilongjiang,Daqing 163001,China)
Abstract:Since 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active neurotoxic metabolite 1-Methy l-4-phenyl- pyridinium (MPP+) have been shown to induce PD, people have done lots of research on the neurotoxicity of MPTP/MPP+. So, MPTP/MPP+ has been widely used to be neurotoxin to induce experimental model of PD. MPTP/MPP+ can induce neuronal apoptosis through various mechanisms, involving Bcl-2, p53, caspase, JNK pathway, ERK pathway and PARP etc. These mechanisms collaborative participate in the control and performance of neuronal apoptosis induced by MPTP/MPP+. This article mainly review the apoptosis mechanisms induced by MPTP/MPP+.
Keywords:1-methyl-4-phenyl-1  2  3  6-tetrahydropyridine (MPTP)  1-methyl-4-phenylpyridinium ion (MPP+)  Apoptosis
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