| 晚期炎症介质-高迁移率族蛋白B-1 |
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| 引用本文： | 欧阳军,彭心宇,李锋.晚期炎症介质-高迁移率族蛋白B-1[J].现代生物医学进展,2010,10(5). |
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| 作者姓名： | 欧阳军 彭心宇 李锋 |
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| 作者单位： | 1. 新疆石河子大学医学院第一附属医院急诊外科,新疆,石河子,832008
2. 新疆石河子大学医学院病理教研室,新疆,石河子,832000 |
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| 摘 要： | 高迁移率族蛋白-1(HMGB-1)是一类广泛存在于真核细胞内的非组核蛋白,是由肿瘤坏死因子(TNF-a)刺激巨噬细胞分泌。HMGB-1全身性炎症反应失控性发展是致使组织损伤和器官衰竭的根本原因,在脓毒症HMGB-1升高程度与感染严重性呈正相关。HMGB-1是炎症晚期重要介质,抑制HMGB-1能够预防内毒素和细菌攻击所致MODS,改善严重脓毒症的预后。尽管对HMGB-1防治作用的确切机制与应用效果尚待深入探讨,但HMGB-1为临床干预脓毒症提供了较宽的时间窗。
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| 关 键 词： | 高迁移率族蛋白-1 炎症介质 脓毒症 |
Late inflammatory mediator as high mobility group albumen-1 |
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| OU Yang-Jun,PENG Xin-Yu,Li Feng.Late inflammatory mediator as high mobility group albumen-1[J].Progress in Modern Biomedicine,2010,10(5). |
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| Authors: | OU Yang-Jun PENG Xin-Yu Li Feng |
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| Institution: | OU Yang-Jun1,PENG Xin-Yu1,Li Feng2 (1.Department of emergency treatment surgery,the First Affiliated Hospital of Shihezi University 2.Department of pathology,Shihezi University school of medicaine Shihezi 832008,Xinjiang,China,) |
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| Abstract: | high mobility group albumen-1(HMGB-1)was macrophage secrete excited by tumor necrosis factor (TNF-a),a group of negative rib nucleoprotein widespread indwell eukaryon intracellular.HMGB-1 all over the body inflammation reaction out of control development is result in the tissues have been injury and organ prostration of fundamental cause.HMGB-1 heightens degree and was infected with severity to offer positive correlation in premie.HMGB-1 is important of the late of inflammatory mediator,restrain HMGB-1 can ... |
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| Keywords: | High mobility group albumen-1 Inflammatory mediator Pyemia |
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