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| 昆仑雪菊提取物对α- 葡萄糖苷酶的抑制作用 | |
| 引用本文： | 张淑鹏,李琳琳 木合布力·阿布力孜 王丽凤 景兆均 毛新民.昆仑雪菊提取物对α- 葡萄糖苷酶的抑制作用[J].现代生物医学进展,2011,11(6):1055-1058. |
| 作者姓名： | 张淑鹏 李琳琳 木合布力·阿布力孜 王丽凤 景兆均 毛新民 |
| 作者单位： | 1. 新疆医科大学药学院药理教研室,新疆,乌鲁木齐,830011;新疆医科大学第-附属医院糖尿病、VIP实验室,新疆乌鲁木齐,830011 2. 新疆医科大学药学院药理教研室,新疆,乌鲁木齐,830011 3. 新疆医科大学新疆地方病分子生物学实验室,新疆乌鲁木齐,830011 4. 新疆雪菊生物科技有限公司,新疆,乌鲁木齐,830011 5. 新疆医科大学第-附属医院糖尿病、VIP实验室,新疆乌鲁木齐,830011;新疆医科大学新疆地方病分子生物学实验室,新疆,乌鲁木齐,830011 |
| 基金项目： | 自治区重点实验室开放课题基金 |
| 摘 要： | 目的:探讨昆仑雪菊提取物对α-葡萄糖苷酶的抑制活性。方法:将昆仑雪菊干燥花序粉碎,分别用水提法和乙醇法制备5种提取物。采用α-葡萄糖苷酶体外活性抑制模型,测定昆仑雪菊的5种提取物对α-葡萄糖苷酶的抑制活性。结果:这5种提取物对α-葡萄糖苷酶活性有较强的抑制作用,抑制活性均高于阿卡波糖。其中提取物Ⅰ的抑制活性最强,IC50=28.2 mg/L。结论:昆仑雪菊提取物具有较高的α-葡萄糖苷酶抑制活性,提示昆仑雪菊在抗糖尿病产品开发方面具有很好的应用前景。 |
| 关 键 词： | 昆仑雪菊 α-葡萄糖苷酶 抑制活性 |
Inhibition of Extracts of Coreopsis Tinctoria Flowers from Kunlun Mountain on a -Glucosidase |
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| ZHANG Shu-peng,LI Lin-lin,Mourboul·Ablise,WANG Li-feng,JING Zhao-jun,MAO Xin-min.Inhibition of Extracts of Coreopsis Tinctoria Flowers from Kunlun Mountain on a -Glucosidase[J].Progress in Modern Biomedicine,2011,11(6):1055-1058. | |
| Authors: | ZHANG Shu-peng LI Lin-lin Mourboul·Ablise WANG Li-feng JING Zhao-jun MAO Xin-min |
| Institution: | ZHANG Shu-peng1,2,LI Lin-lin1,Mourboul·Ablise1,WANG Li-feng3,JING Zhao-jun4,MAO Xin-min2,3(1 Department of Pharmacology,College of Pharmacy,Xinjiang Medical University,2 VIP Laboratory of Diabetes,First Affiliated Hospital of Xinjiang Medical University,3 Xinjiang Key Laboratory of Molecular Biology and Endemic Diseases,4 Biological Technology College of Coreopsis tinctoria flowers From The Kunlun Mountain of Xinjiang,Urumqi 830011,China) |
| Abstract: | Objective:To investigate the inhibited effect of Coreopsis tinctoria flowers extracts from the Kunlun Mountain on alpha-glycosidase.Methods:The dry inflorescence of Coreopsis tinctoria flowers wre crushed,and then five extracts with water and alco-hol extraction were prepared,respectively.The inhibitory activity on alpha-glycosidase of the five extracts of Coreopsis tinctoria flowers were identified by vitro activity inhibition models of alpha-glycosidase.Results:The five extracts have higher inhibition act... |
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