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螺内酯对单肾切除糖尿病大鼠肾脏保护作用研究
引用本文:李庆,陈城,谢利平,刘晓燕,施辉.螺内酯对单肾切除糖尿病大鼠肾脏保护作用研究[J].现代生物医学进展,2011,11(6):1097-1101.
作者姓名:李庆  陈城  谢利平  刘晓燕  施辉
作者单位:1. 南通大学医学院,江苏,南通,226000
2. 南京医科大学,江苏,南京,210029
基金项目:南通市社会发展科技计划:
摘    要:目的:研究螺内酯对单肾切除糖尿病SD大鼠的肾脏保护作用及机制。方法:48只雄性SD大鼠随机分为单肾切除对照组C组、单肾切除糖尿病模型组D组、单肾切除糖尿病螺内酯干预组S组(50mg/kg/day灌胃)。给药6周后观察各组大鼠生化指标改变,肾组织形态学改变,RT-PCR及Western Blot检测肾组织中HGF水平的变化。结果:给药6周后,D组与C组相比,血糖、24h尿蛋白定量、尿素氮、血肌酐和肾重/体重显著增高(P<0.05),螺内酯治疗后可降低糖尿病大鼠的24h尿蛋白定量和肾重/体重,但对其它指标无明显影响;形态学显示,D组与C组相比肾小球系膜区细胞外基质增多及系膜细胞增生,肾小球基底膜增厚,足细胞足突融合、消失;螺内酯治疗后上述病理改变均有不同程度的减轻;RT-PCT、Western Blot结果显示D组和S组HGF表达均增加(P<0.05),而D组HGF表达明显低于螺内酯治疗组。结论:螺内酯可能通过上调HGF的水平从而起到保护糖尿病大鼠肾脏作用。

关 键 词:螺内酯  肝细胞生长因子(HGF)  糖尿病肾病(DN)

Protection of Spironolactone on the Kidney in Diabetic Rats Undergoing Mono-nephrectomy
LI Qing,CHEN Cheng,XIE Li-ping,LIU Xiao-yan,SHI Hui.Protection of Spironolactone on the Kidney in Diabetic Rats Undergoing Mono-nephrectomy[J].Progress in Modern Biomedicine,2011,11(6):1097-1101.
Authors:LI Qing  CHEN Cheng  XIE Li-ping  LIU Xiao-yan  SHI Hui
Institution:LI Qing1,CHEN Cheng2,XIE Li-ping2,LIU Xiao-yan2,SHI Hui1(1 The medicine college of Nantong university,226000,Nantong China,2 Nanjing medical university,210029 Nanjing China)
Abstract:Objective:To investigate the effect of spironolactone on the mono-nephrectomy diabetic SD rats and to explore the possible mechanism.Methods:48 male SD rats were randomly divided into three groups:mono-nephrectomy control rats(group C),mono-nephrectomy diabetic rats(group D),and mono-nephrectomy diabetic rats treated with spironolactone(group S,50mg/kg/day,intragastric administration).6 weeks after treatment,biochemical indicators and renal tissue morphology were detected.The mRNA and protein expression lev...
Keywords:Spironolactone  Hepatocyte growth factor(HGF)  Diabetic nephropathy(DN)  
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