脱细胞真皮基质治疗对糖尿病足综合征合并下肢动脉硬化闭塞患者神经病变和对足部功能的影响

目的:探究脱细胞真皮基质治疗对糖尿病足综合征合并下肢动脉硬化闭塞患者神经病变的缓解作用和对足部功能的影响。方法:选择本院2017.5-2020.5收治的80例糖尿病足综合征合并下肢动脉硬化闭塞患者平均分为观察组和对照组2组,其中对照组患者给与常规干预结合下肢动脉腔内治疗,观察组则在对照组的基础上实施脱细胞真皮基质治疗。分析两组患者治疗前后TCSS评分、神经传导速度、足部功能、治疗效果、创面感染发生率、治疗费用以及并发症发生率的差异。结果:治疗后观察组患者TCSS评分和足部功能评分均较对照组低,神经传导速度较对照组快,差异有统计学意义(P<0.05);观察组患者治疗总有效率、患者创面感染发生率和并发症发生率分别为100.00%、2.50%和2.50%,对照组患者则分别为80.00%、17.50%和55.00%,且对照组住院费用较观察组高,差异有统计学意义(P<0.05)。结论:脱细胞真皮基质治疗对糖尿病足综合征合并下肢动脉硬化闭塞患者神经病变具有确切的缓解作用,尤其对足部功能效果显著,值得临床广泛推广使用。

The Effect of Acellular Dermal Matrix Therapy on Neuropathy and Foot Function in Patients with Diabetic Foot Syndrome and Lower Extremity Arteriosclerosis Occlusion

Objective: To explore the effect of acellular dermal matrix therapy on neuropathy and foot function in patients with diabetic foot syndrome and lower extremity arteriosclerosis occlusion. Methods: The 80 patients with diabetic foot syndrome and arteriosclerosis occlusion of the lower extremities who were admitted to our hospital from May 2017 to May 2020 were divided into two groups, observation group and control group. Patients in the control group were given conventional intervention combined with intracavitary treatment of lower extremity arteries, while the observation group was given acellular dermal matrix treatment on the basis of the control group. The differences of TCSs score, nerve conduction velocity, foot function, treatment effect, wound infection rate,treatment cost and complication rate between the two groups before and after treatment were analyzed. Results: After treatment, TCSS score and foot function score of observation group were lower than control group, and nerve conduction velocity was faster than control group, the difference was statistically significant(P<0.05). The total effective rate, the incidence of wound infection and the incidence of complications in the observation group were 100.00%, 2.50% and 2.50%, respectively, while those in the control group were 80.00%,17.50% and 55.00%, respectively. The hospitalization cost in the control group was higher than that in the observation group, with statistical significance(P<0.05). Conclusion: Acellular dermal matrix therapy has a definite relieving effect on neuropathy in patients with diabetic foot syndrome combined with lower extremity arteriosclerosis occlusion, especially on the function of the foot, and it is worthy of widespread clinical use.