纤维支气管镜吸痰联合肺泡灌洗在肺癌术后合并肺部感染患者中的临床应用价值

目的:探讨纤维支气管镜吸痰联合肺泡灌洗在肺癌术后合并肺部感染患者中的临床应用价值。方法:选择2017年1月-2020年12月间来江苏省人民医院接受治疗的82例肺癌术后合并肺部感染患者,根据随机数字表法分为对照组(纤维支气管镜吸痰、常规治疗)和研究组(纤维支气管镜吸痰、常规治疗、肺泡灌洗),各41例,对照组给予常规抗感染加纤维支气管镜吸痰治疗,研究组在对照组基础上结合肺泡灌洗治疗,观察两组疗效,对比两组呼吸功能、生活质量和外周血辅助性T细胞17(Th17细胞)/调节性T细胞(Treg)变化。结果:研究组的临床总有效率优于对照组(P<0.05)。治疗1周后,两组气道阻力(Raw)、气道峰压(PIP)、呼吸做功(WOB)降低,且研究组低于对照组(P<0.05)。治疗1周后,两组Th17细胞占单个核细胞百分比、白介素-6(IL-6)、白介素-17(IL-17)降低,且研究组低于对照组(P<0.05),治疗1周后,两组Treg细胞占单个核细胞百分比、白介素-10(IL-10)升高,且研究组高于对照组(P<0.05)。治疗1周后,两组社会/家庭状况、生理状况、与医生的关系、功能状况、附加的关注情况、情感状况等领域评分升高,且研究组高于对照组(P<0.05)。结论:纤维支气管镜吸痰联合肺泡灌洗可促进肺癌术后合并肺部感染患者呼吸功能改善,调节外周血Th17细胞/Treg细胞失衡,促进生活质量提高。

Clinical Value of Fiberoptic Bronchoscope Sputum Suction Combined with Alveolar Lavage in Patients with Lung Infection After Lung Cancer Surgery

Objective:To explore the clinical value of fiberoptic bronchoscope sputum suction combined with alveolar lavage in patients with lung infection after lung cancer surgery.Methods:82 patients with lung infection after lung cancer surgery who were treated in Jiangsu Provincial People's Hospital from January 2017 to December 2020 were selected,they were randomly divided into control group(fiberoptic bronchoscope sputum suction and routine treatment)and study group(fiberoptic bronchoscope sputum suction,routine treatment and pulmonary bubble lavage),with 41 cases in each group.The control group was treated with routine anti infection and fiberoptic bronchoscope sputum suction,the study group was treated with alveolar lavage on the basis of the control group.The curative effects of the two groups were observed,and the changes of respiratory function,quality of life and peripheral blood helper T cell 17(Th17 cell)/regulatory T cell(Treg)were compared between the two groups.Results:The total clinical effective rate of the study group was better than that of the control group(P<0.05).1 week after treatment,airway resistance(Raw),peak airway pressure(PIP)and respiratory work(WOB)decreased in the two groups,and the study group was lower than that in the control group(P<0.05).1 week after treatment,the percentage of Th17 cells in mononuclear cells,interleukin-6(IL-6)and interleukin-17(IL-17)in the two groups decreased,and the study group was lower than that in the control group(P<0.05).1 week after treatment,the percentage of Treg cells in mononuclear cells and interleukin-10(IL-10)in the two groups increased,and the study group was higher than that in the control group(P<0.05).1 week after treatment,the scores of social/family status,physiological status,relationship with doctors,functional status,additional attention and emotional status in the two groups increased,and the scores in the study group were higher than those in the control group(P<0.05).Conclusion:Fiberoptic bronchoscope sputum suction combined with alveolar lavage can promote the improvement of respiratory function of patients with lung infection after lung cancer surgery,regulate the imbalance of peripheral blood Th17 cells/Treg cells,and improve the quality of life.