睡眠呼吸暂停综合征患者血脂水平的研究

目的:了解阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆脂质代谢情况。方法:分别检测健康对照组、睡眠呼吸暂停综合征患者组甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A、载脂蛋白B、脂蛋白a、载脂蛋白E含量。进行统计学对比及分析。结果:睡眠呼吸暂停综合征患者的甘油三酯、总胆固醇、高密度脂蛋白、总胆固醇/高密度脂蛋白、载脂蛋白A、载脂蛋白B及载脂蛋白E与健康对照组比较有显著差异,且与其睡眠监测指标有明显相关。结论:OSAHS可导致血浆脂质代谢紊乱,与动脉粥样硬化发生及发展的存在重要的相关性,是独立于年龄、体重、饮食、遗传等原因的冠心病、高血压、脑卒中等心脑血管疾病的发病因素之一。因此,提高对OSAHS的警惕是非常重要的。

Study on blood lipid of patients with obstructive sleep apnea-hypopnea syndrome

Objective:To study the correlation between blood lipid and obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods:In this study,there were two groups:healthy control group (n=40);OSAHS group (n=40).The blood lipid levels in the two groups were examined and analyzed comparatively.Results:There were significant difference between the two groups in triglyceride (TG),total cholestein (TC),high-density lipoprotein (HDL),TC/HDL,apoprotein A (apoA),apoprotein B (apoB) and apoprotein E (apoE).Conclusion:Sleep apnea-hypopnea syndrome can lead to metabolic disorder of blood lipid,which is related to the genesis of ar- teriosclerosis and is one of the causes of coronary artery disease and cerebrovascular disease.Thus much attention should be attached to patients with OSAHS.