| 羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果分析 |
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| 引用本文： | 徐一凡,徐 武,陈维涛,陆天宇,戴宇翔,梁维邦,金 伟.羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果分析[J].现代生物医学进展,2019,19(3):454-457. |
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| 作者姓名： | 徐一凡 徐 武 陈维涛 陆天宇 戴宇翔 梁维邦 金 伟 |
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| 作者单位： | 南京大学医学院附属鼓楼医院神经外科 |
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| 基金项目： | 国家自然科学基金面上项目（81171153） |
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| 摘 要： | 目的:探讨羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果。方法:选择我院2015年1月～2016年6月收治的86例三叉神经痛患者,按照随机数表法分为对照组和研究组,每组43例。对照组予以羟考酮麻醉,研究组予以羟考酮联合右美托咪定麻醉。比较两组手术前后的血压、平均动脉压、血清白细胞介素-8(IL-8)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平的变化,临床疗效、复发情况及不良反应的发生情况。结果:术前,两组血压、平均动脉压、血清CRP、TNF-α比较差异无统计学意义(P0.05);术后,两组血压、平均动脉压、血清IL-8、CRP、TNF-α水平均较术前下降,且研究组血压、平均动脉压均显著高于对照组,而血清IL-8、CRP、TNF-α水平均明显低于对照组(P0.05)。两组优良率、复发率比较差异无统计学意义(P0.05)。两组均有心动过缓、瘙痒、头晕、恶心呕吐发生,但研究组不良反应发生率显著低于对照组(P0.05)。结论:羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果确切,能够显著减轻炎症反应,缓解疼痛。
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| 关 键 词： | 三叉神经微血管减压术 羟考酮 右美托咪定 炎性反应 预后 |
| 收稿时间： | 2018/5/8 0:00:00 |
| 修稿时间： | 2018/5/30 0:00:00 |
Analysis of the Application Effect of Oxycodone Combined with Dexmedetomidine on the Trigeminal Nerve Microvascular Decompression |
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| XU Yi-fan,XU Wu,CHEN Wei-tao,LU Tian-yu,DAI Yu-xiang,LIANG Wei-bang and JIN Wei.Analysis of the Application Effect of Oxycodone Combined with Dexmedetomidine on the Trigeminal Nerve Microvascular Decompression[J].Progress in Modern Biomedicine,2019,19(3):454-457. |
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| Authors: | XU Yi-fan XU Wu CHEN Wei-tao LU Tian-yu DAI Yu-xiang LIANG Wei-bang and JIN Wei |
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| Institution: | Department of Neurosurgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu, 210008, China,Department of Neurosurgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu, 210008, China,Department of Neurosurgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu, 210008, China,Department of Neurosurgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu, 210008, China,Department of Neurosurgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu, 210008, China,Department of Neurosurgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu, 210008, China and Department of Neurosurgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, Jiangsu, 210008, China |
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| Abstract: | |
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| Keywords: | Trigeminal nerve microvascular decompression Oxycodone Dexmedetomidine Inflammatory response Prognosis |
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