不同病情妊娠高血压综合征患者凝血指标及血小板参数检测的临床价值及其妊娠结局研究

目的:研究不同病情妊娠高血压综合征患者凝血指标及血小板参数检测的临床价值及其妊娠结局。方法:2017年2月～2018年12月期间,我院收治的120例妊娠高血压综合征患者作为研究对象,将其按照疾病严重程度的不同分为轻度组45例、中度组40例以及重度组35例。分别比较三组患者的各项凝血指标、血小板参数、产妇不良妊娠结局以及新生儿不良妊娠结局。结果:重度组部分凝血活酶时间(APTT)、凝血酶时间(TT)较轻度组和中度组缩短,而纤维蛋白原(FIB)较轻度组和中度组升高(P0.05),且中度组FIB高于轻度组(P0.05)。重度组血小板数量(PLT)低于轻度组和中度组,而平均血小板体积(MPV)高于轻度组和中度组(P0.05),中度组PLT低于轻度组,而MPV高于轻度组(P0.05)。重度组胎盘早剥、剖腹产、产后出血的发生率高于中度组和轻度组,且中度组高于轻度组(P0.05)。重度组新生儿窒息、早产、呼吸窘迫的发生率高于中度组、轻度组,且中度组高于轻度组(P0.05)。结论:临床工作中可通过联合检测凝血指标及血小板参数,从而有利于评估妊娠高血压综合征患者的病情严重程度,同时有助于预测妊娠结局。

Clinical Value and Pregnancy Outcome of Detection of Coagulation Parameters and Platelet Parameters in Patients with Pregnancy Hypertension Syndrome with Different Conditions

ABSTRACT Objective: To study the clinical value and pregnancy outcome of detection of coagulation parameters and platelet parameter detection in patients with gestational hypertension syndrome with different conditions. Methods: From February 2017 to December 2018, 120 patients with gestational hypertension syndrome who were admitted to our hospital were selected as study subjects. The patients were divided into mild group (45 cases), moderate group (40 cases) and severe group (35 cases) according to the severity of the disease. The coagulation parameters, platelet parameters, maternal adverse pregnancy outcomes and neonatal adverse pregnancy outcomes were compared among the three groups. Results: The activated partial thromboplastin time (APTT) and rthrombin time (TT) in the severe group were shorter than those in the mild group and moderate group, while fibrinogen (FIB) were higher than that in the mild group and moderate group (P<0.05). The FIB of the moderate group was higher than that of the mild group (P<0.05). The platelet count (PLT) in the severe group were lower than that in the mild group and moderate group, and mean platelet volume (MPV) was higher than that in the mild group and moderate group (P<0.05). PLT in the moderate group was lower than that in the mild group, and MPV was higher than that in the mild group (P<0.05). The incidence of placental abruption, cesarean section and postpartum hemorrhage in the severe group were higher than those in the moderate group and mild group, and those in the moderate group were higher than those in the mild group (P<0.05). The incidence of neonatal asphyxia, preterm birth and respiratory distress in the severe group were higher than those in the moderate group and mild group, while those in the moderate group were higher than those in the mild group (P<0.05). Conclusion: In clinical work, coagulation parameters and platelet parameters can be detected jointly, so it is helpful to evaluate the condition of severity of patients with gestational hypertension syndrome. It is also helpful in predicting pregnancy outcomes.