甲状腺功能减退患者血清甲状腺激素、同型半胱氨酸及血脂水平测定的临床意义

目的:探讨甲状腺功能减退患者血清同型半胱氨酸(Hcy)、甲状腺激素(TH)及血脂水平测定的临床意义。方法:选取2016年2月-2017年2月期间我院收治的甲状腺功能减退患者101例为观察组,选取同期于我院体检的健康志愿者80例为对照组。检测所有研究对象甲状腺素(FT4)和三碘甲状腺原氨酸(FT3)、Hcy及血脂甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]变化水平。比较观察组治疗前后、对照组与观察组治疗前FT3、FT4、Hcy及血脂水平,采用Pearson相关性分析血清Hcy与FT3、FT4、血脂水平的相关性。结果:观察组患者治疗后FT3、FT4均较治疗前升高,Hcy、TC、LDL-C均较治疗前降低(P0.05),而观察组患者治疗前后TG、HDL-C比较差异无统计学意义(P0.05)。观察组治疗前FT3、FT4、HDL-C水平明显低于对照组,而Hcy、TG、TC、LDL-C则明显高于对照组(P0.05)。经Pearson相关性分析显示,甲状腺功能减退患者Hcy与FT3、FT4呈负相关(P0.05),与TC、TG呈正相关(P0.05),而与LDL-C、HDL-C无相关性(P0.05)。结论:甲状腺功能减退患者的FT3、FT4、Hcy及血脂水平表达异常,且Hcy与FT3、FT4、血脂水平密切相关,临床上可通过监测甲状腺功能减退患者的上述指标,有助于评估患者的病情程度。

Clinical Significance of Serum Thyroid Hormones, Homocysteine and Blood Lipid Levels in Patients with Hypothyroidism

ABSTRACT Objective: To investigate the clinical significance of homocysteine(Hcy), serum thyroid hormone(TH) and blood lipid levels in patients with hypothyroidism. Methods: 101 cases of hypothyroidism who were admitted to our hospital from February 2016 to February 2017 were selected as the observation group, 80 healthy volunteers in our hospital during the same period were selected as control group. Thyroxine(FT4), three iodine thyroxine(FT3), Hcy and blood lipid levelstriglyceride(TG), total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C)] in the all subjects were detected. The levels of FT3, FT4, Hcy and blood lipid in the observation group before and after treatment, the control group and the observation group before treatment were compared. The correlation of serum Hcy, FT3, FT4 and blood lipid levels were analyzed by Pearson correlation analysis. Results: The FT3 and FT4 of the observation group were higher than those before treatment, while Hcy, TC and LDL-C were all lower than those before treatment(P<0.05). But there were no statistical differences between TG and HDL-C in patients with observation group before and after treatment (P>0.05). The levels of FT3, FT4 and HDL-C in the observation group were significantly lower than those in the control group before treatment, while the Hcy, TG, TC and LDL-C were significantly higher than those in the control group(P<0.05). Pearson correlation analysis showed that Hcy was negatively correlated with FT3 and FT4 in hypothyroidism patients(P<0.05), and there was a positive correlation with TC and TG(P<0.05), but there were not correlation with LDL-C and HDL-C(P>0.05). Conclusion: The levels of FT3, FT4, Hcy and lipid in patients with hypothyroidism were abnormal, and Hcy is closely related to the level of FT3, FT4 and blood lipid. These indicators can be monitored clinically in patients with hypothyroidism, it helps to assess the extent of the patient''s condition.