健脾安肠汤联合匹维溴胺治疗肠易激综合征的临床疗效及对血清5-HT、CGRP、SP、VIP水平的影响

目的:探讨健脾安肠汤联合匹维溴胺治疗肠易激综合征的临床疗效及对血清5-羟色胺(5-HT)、降钙素基因相关肽(CGRP)、结肠黏膜P物质(SP)、血管活性肠态(VIP)水平的影响。方法:选择2017年1月至2017年12月本院接诊的98例肠易激综合征患者作为研究对象,按随机数表法分为观察组(n=45)和对照组(n=53),对照组单纯采用匹维溴胺进行治疗,观察组在此基础上联合健脾安肠汤进行治疗。比较两组患者的临床疗效及治疗前后胃肠症状改善情况、血清5-HT、CGRP、SP、VIP水平、炎性因子水平、焦虑(SAS)、抑郁(SDS)评分的变化。结果:治疗后,观察组总有效率(93.33%)心脏高于对照组(71.70%,P0.05);观察组患者恶心呕吐、腹痛腹泻、排便次数及大便性质症状评分,血清5-HT、CGRP、SP、VIP、IL-8、IL-6水平、焦虑及抑郁评分均明显低于对照组(均P0.05),而血清IL-10水平显著高于对照组(P0.05)。结论:健脾安肠汤联合匹维溴胺治疗肠易激综合征的临床效果显著优于单纯采用匹维溴胺治疗,可有效调节机体胃肠激素分泌和临床症状,提高患者患者生活质量。

Curative Efficacy of JianPiAnChang Soup Combined with Pinaverium Bromide in the Treatment of Irritable Bowel Syndrome and Its Effects on the serum Levels of 5-HT, CGRP, SP and VIP

ABSTRACT Objective: To study the curative efficacy of JianPiAnChang soup combined with pinaverium bromide in the treatment of Irritable bowel syndrome and its effects on the serum levels of 5-HT, CGRP, SP and VIP. Methods: 98 patients of Irritable bowel syndrome who received therapy from Jan 2017 to Dec 2017 in our hospital, randomly divided into observation group( n=45) and control group( n=53), the control group was only treated with pinaverium bromide, The observation group was treated with JianPiAnChang soup on the basis of the control group. The clinical efficacy, improvement of gastrointestinal symptoms, serum 5-HT, CGRP, SP, VIP, inflammatory factors, Self-Rating Anxiety Scale (SAS) and Self-rating depression scale (SDS) scores were compared between the two groups before and after treatment. Results: After treatment, The total effective rate of the observation group (93.33%) was higher than that of the control group (71.70%)(P<0.05), the observation group patients with nausea and vomiting, abdominal pain, diarrhea, frequency of bowel movements and stool symptoms were lower than the control group(P<0.05). The levels of serum 5-HT, CGRP, SP, VIP, serum IL-8, IL-6 and the anxiety and depression scores in the observation group were lower than those in the control group, and the IL-10 level was higher than that in the control group(P<0.05). Conclusion: The clinical effect of JianPiAnChang soup combined with pinaverium bromide in the treatment of irritable bowel syndrome is remarkable, which is better than that of Pivebromide alone. It can effectively regulate the secretion of gastrointestinal hormones, clinical symptoms and improve the quality of life of patients.