膝骨关节炎人群中血清锌与血脂紊乱的相关性研究

目的:探讨膝骨关节炎(Osteoarthritis,OA)人群中血清锌(Zinc,Zn)水平与血脂紊乱的相关性。方法:采用横断面研究,纳入在中南大学湘雅医院健康管理中心进行健康体检的935例膝OA患者作为研究对象。通过分光光度法检测纳入研究对象的血清Zn水平,并通过贝克曼库尔特AU 5800全自动生化分析仪检测血脂水平。根据血清Zn水平将研究人群进行五分类,采用Logistic回归模型探讨血清Zn水平与血脂紊乱的相关性。结果:Logistic回归模型结果显示,校正年龄和性别后,与第1分类(最低)血清Zn组相比,第2-5分类血清Zn组血脂紊乱患病率比值比和95%可信区间(95%confidence interval, 95%CI)分别为1.66 (95%CI:1.08, 2.56)、1.25 (95%CI:0.81, 1.93)、1.61 (95%CI:1.04, 2.49)和3.04 (95%CI:1.97, 4.68)(趋势检验P0.001)。多因素校正和性别亚组分析结果无明显变化。结论:膝OA人群血清Zn水平与血脂紊乱患病呈正相关,OA人群高血Zn可能为发生血脂紊乱的危险因素。

Association between Serum Zinc Level and Dyslipidemia in the Knee Osteoarthritis Patients

ABSTRACT Objective: To examine the association between serum zinc (Zn) and dyslipidemia in knee osteoarthritis (OA) patients. Methods: A cross-sectional study was conducted in the Department of Health Examination Center, Xiangya Hospital, Central South University, and 935 knee OA patients were included. Serum Zn was measured by spectrophotometry method and blood lipid assessment was performed on a Beckman Coulter AU 5800 system. The serum Zn concentration was classified into five categories. Results: Compared with the lowest quintile, the age-sex adjusted odds ratios and 95% confidence interval (95% CI) for dyslipidemia were 1.66 (95% CI: 1.08, 2.56), 1.25 (95% CI: 0.81, 1.93), 1.61 (95% CI: 1.04, 2.49), and 3.04 (95% CI: 1.97, 4.68) from the second to fifth quintiles of serum Zn, respectively (P value for trend <0.001). The findings were not materially altered by adjustment for more potential confounders, and similar results were observed for men and women separately. Conclusion: The findings of the present study indicated that there was a positive association between the level of serum Zn and dyslipidemia in knee OA patients, and high level of Serum Zn may be a risk factor for developing dyslipidemia.