| 生脉注射液联合曲美他嗪治疗缺血性心肌病合并肾功能不全的临床疗效分析 |
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| 引用本文： | 杨宝刚,王庆凯,尹广利,马明静,杨 静,张成成.生脉注射液联合曲美他嗪治疗缺血性心肌病合并肾功能不全的临床疗效分析[J].现代生物医学进展,2019,19(5):942-945. |
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| 作者姓名： | 杨宝刚 王庆凯 尹广利 马明静 杨 静 张成成 |
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| 作者单位： | 河北省沧州中西医结合医院心内科; |
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| 基金项目： | 河北省中医药管理局科研计划项目(2015288) |
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| 摘 要： | 目的:研究生脉注射液联合曲美他嗪治疗缺血性心肌病合并肾功能不全的临床疗效。方法:选取2015年3月至2017年3月我院收治的100例缺血性心肌病合并肾功能不全患者,按照随机数表法分为观察组(n=50)和对照组(n=50)。对照组采用曲美他嗪治疗,观察组采用生脉注射液联合曲美他嗪治疗。观察和比较两组的治疗疗效、治疗前后心功能指标(左心室射血分数(LVEF)、左室收缩末径(LVESD)、左室舒张末期内径(LVEDD))、肾功能指标(血肌酐(Scr),尿素氮(BUN))、心肌损伤标志物(血清胱抑素(Cys C)、同型半胱氨酸(HCY)、脑钠肽(BNP))水平的变化。结果:治疗后,观察组总有效率显著高于对照组92.30%(48/52) vs.70.83%(34/48)](P0.05),LVEDD、LVESD水平均显著低于对照组(51.21±8.54)mm vs.(56.63±10.83)mm,(42.91±6.30)mm vs.(45.86±7.32)mm](P0.05),LVEF水平均显著高于对照组(46.02±7.85)%vs.(41.20±8.84)%](P0.05),Scr、BUN水平均显著低于对照组(164.30±17.95)μmol/L vs.(211.75±19.31)μmol/L;(8.12±0.76)mmol/L vs.(11.74±1.72)mmol/L](P0.05)。血清Cys C、HCY、NT-Pro BNP水平均显著低于对照组(0.90±0.21)mg/L vs 1.52±0.34)mg/L (12.34±3.89)μmol/L vs.(20.86±5.28)μmol/L,(298.47±78.41)ng/L vs.(402.35±92.76)ng/L](P0.05)。结论:生脉注射液联合曲美他嗪治疗缺血性心肌病合并肾功能不全的的临床疗效显著优于单用曲美他嗪治疗,其可有效改善患者心、肾功能,减轻心肌细胞损伤。
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| 关 键 词： | 生脉注射液 曲美他嗪 缺血性心肌病 肾功能不全 |
| 收稿时间： | 2018/10/8 0:00:00 |
| 修稿时间： | 2018/10/31 0:00:00 |
Analysis of the Clinical Efficacy of Shengmai Injection plus Trimetazidine in the Treatment of Ischemic Cardiomyopathy Combined with Renal Insufficiency |
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| YANG Bao-gang,WANG Qing-kai,YIN Guang-li,MA Ming-jing,YANG Jing and ZHANG Cheng-cheng.Analysis of the Clinical Efficacy of Shengmai Injection plus Trimetazidine in the Treatment of Ischemic Cardiomyopathy Combined with Renal Insufficiency[J].Progress in Modern Biomedicine,2019,19(5):942-945. |
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| Authors: | YANG Bao-gang WANG Qing-kai YIN Guang-li MA Ming-jing YANG Jing and ZHANG Cheng-cheng |
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| Institution: | Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, 061001, China,Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, 061001, China,Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, 061001, China,Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, 061001, China,Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, 061001, China and Department of Cardiology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, 061001, China |
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| Abstract: | |
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| Keywords: | Shengmai injection Trimetazidine Ischemic cardiomyopathy Renal function protection Cystatin |
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