自拟柴芍护膜汤联合莫沙必利治疗反流性食管炎的临床效果观察

目的:研究自拟柴芍护膜汤联合莫沙必利治疗反流性食管炎的临床效果和可能机制。方法:选择2015年12月～2018年12月我院内科杂病门诊治疗的70例反流性食管炎患者,将其随机分为两组。对照组服用莫沙必利,每次5 mg,每天3次;观察组联合服用自拟柴芍护膜汤以及莫沙必利。比较两组患者治疗后的临床治疗效果,治疗前后泛酸、烧心、脘腹胀满、嗳气、呃逆、情志抑郁、善太息、食欲不振以及嘈杂等症状的严重程度、血浆胃动素和血清胃泌素水平的变化。结果:治疗后,观察组的有效率为91.43%,明显高于对照组(71.43%,P0.05)。两组治疗后的泛酸、烧心、脘腹胀满、嗳气、呃逆、情志抑郁、善太息、食欲不振以及嘈杂评分均较治疗前明显降低(P0.05),且观察组的上述症状评分明显低于对照组(P0.05);两组治疗后的血浆胃动素和血清胃泌素水平均较治疗前明显升高(P0.05),且观察组以上指标均明显高于对照组(P0.05)。结论:自拟柴芍护膜汤联合莫沙必利能有效改善反流性食管炎的临床症状,其作用机制可能与提高血浆胃动素和血清胃泌素水平有关。

Observation on the Clinical Effect of Chaishao Humo Decoction Combined with Mosapride in the Treatment of Reflux Esophagitis

ABSTRACT Objective: To investigate the clinical effects and possible mechanisms of Chaishao Humo Decoction combined with mosapride in the treatment of reflux esophagitis. Methods: Selected 70 cases of patients with reflux esophagitis who were treated in our hospital from December 2016 to December 2018, and divided into two groups randomly. The control group was treated with mosapride, 5 mg each time, tid; the observation group was treated with Chaishao humo Decoction and mosapride. The clinical effect after treatment, the severity of pantothenic acid, heartburn, abdominal distention, belching, hiccup, depression, good rest, loss of appetite and noise and the changes of the levels of plasma motilin and serum gastrin before and after treatment were compared between two groups. Results: After treatment, the effective rate in the observation group was 91.43%, significantly higher than that in the control group (71.43%, P<0.05). After treatment, the scores of pantothenic acid, heartburn, abdominal distention, belching, hiccup, depression, good rest, loss of appetite and noise in both groups were significantly reduced compared with before treatment(P<0.05). The scores of the above symptoms in the observation group were significantly lower than those in the control group (P<0.05). The levels of plasma motilin and serum gastrin in both groups were significantly increased after treatment compared with before treatment(P<0.05), and the levels of above indicators in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: Chaishao humo Decoction combined with mosapride can effectively improve the symptoms of reflux esophagitis. Its mechanism may be related to increasing the expression of plasma motilin and serum gastrin.