肾衰宁胶囊联合血液透析对慢性肾功能衰竭患者肾功能及血液流变学的影响

目的:探讨肾衰宁胶囊联合血液透析对慢性肾功能衰竭患者肾功能及血液流变学的影响。方法:选取中国医科大学本溪中心医院于2015年1月-2017年9月期间收治的慢性肾功能衰竭患者80例为研究对象。根据随机数字表法将患者分为对照组(n=40)与研究组(n=40),两组患者均给予血液透析治疗,研究组在此基础上联合使用肾衰宁胶囊治疗,疗程均为3个月。观察并比较两组患者治疗3个月后临床疗效及不良反应发生情况,比较两组患者治疗前、治疗3个月后血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(eGFR)水平及全血高切黏度、全血低切黏度、血浆黏度、红细胞比容。结果:研究组患者总有效率为92.50%(37/40),高于对照组的67.50%(27/40),差异有统计学意义(P0.05)。两组患者治疗3个月后Scr、BUN水平较治疗前降低,且研究组低于对照组(P0.05);而两组患者治疗3个月后eGFR水平较治疗前升高,且研究组高于对照组(P0.05)。研究组患者治疗3个月后的全血高切黏度、全血低切黏度、血浆黏度以及红细胞比容均低于对照组(P0.05)。对照组不良反应发生率为7.50%,与研究组的10.00%比较差异无统计学意义(P0.05)。结论:肾衰宁胶囊联合血液透析对慢性肾功能衰竭患者有较好的治疗效果,能够改善患者肾功能状况,同时稳定患者血液流变学,并且安全性较好。

Effect of Shen Shuai Ning Capsule Combine with Hemodialysis on Renal Function and Hemorheology in Patients with Chronic Renal Failure

ABSTRACT Objective: To investigate the effect of Shen Shuai Ning capsule combine with hemodialysis on renal function and hemorheology in patients with chronic renal failure. Methods: 80 patients with chronic renal failure who were treated in Benxi Central Hospital of China Medical University from January 2015 to September 2017 were selected as the subjects. The patients were divided into control group (n=40) and study group (n=40) according to the number table method, the two groups were given hemodialysis treatment, the study group on the basis of combination of Shen Shuai Ning capsule, the course of treatment was 3 months. The clinical efficacy and adverse reaction of two groups after 3 months of treatment were observed and compared, the serum creatinine (Scr), urea nitrogen (BUN), glomerular filtration rate (eGFR) level and whole blood viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit between the two groups before and after treatment of 3 months were compared. Results: The total effective rate of the study group was 92.50% (37/40), which was significantly higher than 67.50% (27/40) of the control group, the difference was statistically significant (P<0.05). The levels of Scr and BUN in the two groups after 3 months of treatment was lower than those before treatment, and the study group was lower than that of the control group (P<0.05), the level of eGFR in the two groups after 3 months of treatment was higher than that before treatment, and the study group was higher than that of the control group (P<0.05). The whole blood viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit in the study group after 3 months of treatment were lower than those of the control group (P<0.05). The incidence of adverse reactions in the control group was 7.50%, and there was no significant difference compared with the 10.00% in the study group (P>0.05). Conclusion: Shen Shuai Ning capsule combine with hemodialysis has a good therapeutic effect on patients with chronic renal failure, it can improve renal function and stabilize blood rheology. And the safety is better.