不同比例新鲜冰冻血浆对大量输血患者凝血功能的影响

目的:探讨不同比例输注新鲜冰冻血浆对大量输血患者凝血功能的影响。方法:回顾性分析本院2018年1月至2018年12月收治的123例大量输血患者的临床资料,依据所输注新鲜冰冻血浆与红细胞比例不同,将其分为低比例组(1:3)、中比例组(1:2)、高比例组(1:1),比较三组患者输血前后凝血功能、血小板计数及电解质变化。结果:输血后,三组患者FIB较输血前明显降低,而PT、APTT较输血前显著升高(P0.05),高比例组PT和APTT明显低于中比例组和低比例组,FIB、血小板均高于中比例组和低比例组(P0.05),电解质水平优于低比例组和中比例组(P0.05)。结论:在大量输血时,提高血浆与红细胞比例有利于改善大量输血患者凝血功能障碍,减少电解质紊乱。

Effects of Different Proportions of Plasma and Erythrocyte on the Coagulation Function of Patients with Massive Transfusion

ABSTRACT Objective: To discuss the effects of different proportion of fresh frozen plasma infusion on coagulation function in pa- tients with massive blood transfusion. Methods:The clinical data of 123 patients with massive blood transfusion admitted to our hospital from January 2018 to December 2018 were retrospectively analyzed, According to the different proportions of blood proportion group (1:2), and high proportion group (1:1). Coagulation function, platelet count and electrolyte change were compared before and after transfu- sion. Results: After transfusion, FIB in the three groups was significantly lower than that before blood transfusion, while PT and APTT were significantly higher than those before blood transfusion(P<0.05). The PT and APTT of the high-proportion group were obviously lower than that of the medium-proportion group and the low-proportion group, while the FIB and platelets of the high-proportion group was higher than that of the medium-proportion group and the low-proportion group(P<0.05). The electrolyte levels in the high proportion group after transfusion were better than those in the low proportion group and the middle proportion group (P<0.05). Conclusion: In the case of a large number of blood transfusions, increasing the ratio of plasma to red blood cells is beneficial to improve coagulopathy and electrolyte imbalance in a large number of transfusion patients.