老年急性冠脉综合征患者血尿酸与血脂、HCY及hs-CRP水平的关系研究

目的:研究老年急性冠脉综合征(ACS)患者血尿酸(UA)与血脂、同型半胱氨酸(HCY)及超敏C反应蛋白(hs-CRP)水平的关系。方法:选择从2014年2月到2017年9月在重庆三峡中心医院接受治疗的老年ACS患者59例作为研究对象。急性心肌梗死(AMI)患者32例,即为AMI组;不稳定型心绞痛(UAP)患者27例,即为UAP组。另选同期30例在我院接受体检的健康志愿者作为对照组,对比各组UA、HCY、hs-CRP水平以及血脂水平,并分析患者UA与血脂、HCY及hs-CRP水平的相关性。结果:AMI组和UAP组的UA、HCY及hs-CRP水平均高于对照组,且AMI组又高于UAP组(P0.05)。AMI组和UAP组的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)水平均高于对照组,AMI组又高于UAP组(P0.05);AMI组和UAP组的高密度脂蛋白(HDL)水平低于对照组,且AMI组又低于UAP组(P0.05)。根据Spearman法分析相关性可知,患者UA与HCY、hs-CRP、TC、TG及LDL均呈正相关,与HDL呈负相关(P0.05)。结论:老年ACS患者UA、HCY、hs-CRP、TC、TG及LDL水平均较高,HDL水平较低,且UA与血脂、HCY以及hs-CRP均具有较好的相关性,临床可尝试将其作为重点监测靶点,从而应用于ACS患者的诊治。

Relationship Research between Blood Uric Acid and Blood Lipid, HCY and hs-CRP Levels in Elderly Patients with Acute Coronary Syndrome

ABSTRACT Objective: To study the relationship between blood uric acid (UA) and blood lipid, homocysteine (HCY) and hyper- sensitivity C reactive protein (hs-CRP) in elderly patients with acute coronary syndrome (ACS). Methods: 59 elderly patients with ACS who were treated in Chongqing Three Gorges Central Hospital from February 2014 to September 2017 were selected as the subjects, 32 patients with acute myocardial infarction (AMI) were recorded as AMI group, 27 patients with unstable angina pectoris (UAP) were recorded as UAP group.30 volunteers who were received physical examination in our hospital at the same period were selected as the control group. The levels of UA, HCY and hs-CRP and blood lipids in each group were compared, and the correlation between UA and levels of blood lipids, HCY and hs-CRP was analyzed. Results: The levels of UA, HCY and hs-CRP in AMI group and UAP group were significantly higher than those in the control group, and the AMI group was higher than that of the UAP group (P<0.05). The levels of to- tal cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) in AMI group and UAP group were significantly higher than those in the control group, and the AMI group was higher than that of the UAP group(P<0.05). The level of high density lipoprotein (HDL) in AMI group and UAP group was lower than that of the control group, and AMI group was lower than that of the UAP group (P<0.05). According to the analysis of the correlation of Spearman, UA of patient was positively correlated with HCY, hs-CRP, TC, TG and LDL, and which was negatively correlated with HDL(P<0.05). Conclusion: The levels of UA, HCY, hs-CRP, TC, TG and LDL in the elderly patients with ACS are all higher, the level of HDL was lower, and UA has good correlation with blood lipid, HCY and hs-CRP. It can be tried as a key monitoring target in clinical trials, so it can be applied to the diagnosis and treatment of patients with ACS.