ART患者早期流产组织染色体异常及相关因素分析

目的:分析ART患者早期流产组织染色体异常及其相关影响因素。方法:回顾性分析2013-2017年ART患者行早期流产组织染色体检查的409例样本,分析胚胎染色体非整倍性发生及其与女方年龄、不孕年限、不孕因素、促排卵指标之间的关系。结果:ART流产患者中,流产组织染色体非整倍性发生率为57.46%,发生频次以16三体占比最高(23.95%),其次是22三体(13.45%)及Turner(9.24%)。流产组织染色体非整倍性患者平均年龄高于染色体整倍性患者(P0.001)。16三体组患者年龄低于22三体(P0.01)及Turner组(P0.05)。16三体组患者平均Gn使用量低于22三体组(P0.05)。16三体组患者移植15天血HCG值低于22三体(P0.05)及Turner组(P0.01)。结论:ART患者流产组织染色体非整倍性与女方年龄正相关,但16三体及Turner的发生与女方年龄相关性不大,且16三体更容易引发早期流产。

A Study on Chromosome Abnormity and Its Factors in Early Abortion Tissue from ART Patients

ABSTRACT Objective: To investigate the chromosome abnormity and its related factors in early abortion tissue from ART patients. Methods: A retrospective analysis was performed on the early abortion tissue from 409 cases of ART patients from 2013 to 2017, and the relationship between embryo chromosome aneuploidy and female age, infertility years, infertility factors and ovulation promotion index were analyzed. Results: In 409 cases of ART patients, the percentage of embryo chromosome aneuploidy in abortion tissue was 57.46%, in which the top three proportion was 16 trisomy (23.95%), 22 trisomy (13.45%) and Turner (9.24%). The average age of female patients with chromosome aneuploidy embryo was significantly older than that of female patients with chromosome euploidy embryo(P<0.001). The average age of female patients with 16 trisomy embryo was significantly youngerr than that of female patients with 22 trisomy em- bryo(P<0.01) and that of female patients with Turner embryo(P<0.05). The average gonadotrophindose in patients with 16 trisomy em- bryo was less than that of patients with 22 trisomy embryo(P<0.05). The HCG level on the 15th day after transplanting in patients with 16 trisomy embryo undered that in patients with 22 trisomy embryo(P<0.05) and that in patients with Turner embryo (P<0.01). Conclusion: The occurrence frequency of embryo chromosome aneuploidy in early abortion tissue from ART patients had a positive correlation with the female age. However, the occurrence frequency of 16 trisomy and Turner embryo showed no correlation. Furthermore, the 16 trisomy embryo was a more likely factor resulting in early abortion.