急性缺血性脑卒中患者血清GAL3、CXCL12水平与病情严重程度和预后的关系研究

目的:探讨急性缺血性脑卒中(AIS)患者血清半乳糖凝集素3(GAL3)、血清趋化因子12(CXCL12)水平与病情严重程度和预后的关系。方法:选取成都市第五人民医院于2016年2月～2018年9月期间接收的AIS患者138例为观察组,另选取同期来该院行健康体检的志愿者60例为对照组。其中观察组根据美国国立卫生研究所中风量表(NIHSS)评分分为轻症组(n=42,4分),中症组(n=61,4～15分),重症组(n=35,15分),根据改良RABKIN量表(m RS)评分分为预后良好组(n=82)和预后不良组(n=56)。比较对照组、观察组的血清GAL3、CXCL12水平,分析不同NIHSS得分、不同预后的血清GAL3、CXCL12水平,采用Pearson相关性分析血清GAL3、CXCL12水平与NIHSS评分、m RS评分的相关性。结果:观察组血清GAL3、CXCL12水平均显著高于对照组,差异有统计学意义(P0.05)。重症组、中症组AIS患者血清GAL3、CXCL12水平高于轻症组,且重症组高于中症组,差异有统计学意义(P0.05)。预后不良组的AIS患者血清GAL3、CXCL12水平均高于预后良好组,差异有统计学意义(P0.05)。Pearson相关性分析结果可知,血清GAL3、CXCL12水平与NIHSS评分、m RS评分均呈正相关(P0.05)。结论:AIS患者的血清GAL3、CXCL12水平均异常升高,且其升高程度与AIS患者病情严重程度及预后息息相关。

Studies on the Relationship between Serum GAL3, CXCL12 Levels, Severity of Illness and Prognosis in Patients with Acute Ischemic Stroke

ABSTRACT Objective: To explore the relationship between the serum galactose agglutinin 3 (GAL3), chemokine C-X-C motif-ligand-12 (CXCL12) levels, severity of illness and prognosis in patients with acute ischemic stroke (AIS). Methods: 138 patients with AIS who were received in Chengdu Fifth People''s Hospital from February 2016 to September 2018 were selected as observation group, and 60 healthy volunteers from the hospital during the same period were selected as the control group. The observation group were divided into mild group (n=42, <4 points), moderate group (n=61, 4~15 points), and severe group (n=35, >15 points) according to the National Institutes of Health Stroke Scale (NIHSS) score, while according to the Modified RABKIN Scale (mRS) score, the patients were divided into good prognosis group (n=82) and poor prognosis group (n=56). The levels of serum GAL3 and CXCL12 in control group and observation group were compared. The levels of serum GAL3 and CXCL12 in different NIHSS scores and prognosis were analyzed. The correlation between the levels of serum GAL3, CXCL12 and NIHSS score, mRS score were analyzed by Pearson method. Results: The levels of serum GAL3 and CXCL12 in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). The levels of serum GAL3 and CXCL12 in AIS patients that in severe group and moderate group were higher than those in mild group, and those in severe group were higher than those in moderate group, the differences were statistically significant (P<0.05). The levels of serum GAL3 and CXCL12 in AIS patients in poor prognosis group were higher than those in AIS patients in good prognosis group, the differences were statistically significant (P<0.05). Pearson correlation analysis showed that the levels of serum GAL3 and CXCL12 were positively correlated with NIHSS score and mRS score (P<0.05). Conclusion: The levels of serum GAL3 and CXCL12 in AIS patients are abnormally elevate, which is closely related to the severity and prognosis of AIS patients.