高强度聚焦超声在药物控制释放的应用及进展

高强度聚焦超声能够以一种非侵入性的方式有效地穿透身体内部组织,聚焦在深层组织中一个很小的空间区域内,产生很强的声能,这些能量被组织吸收引起局部温度的升高。当温度到达热敏脂质体的相变温度时,磷脂烷基链构象的会发生改变,导致脂质体的通透性增强,从而能够促进药物的释放。因此,高强度聚焦超声可以被用作外源刺激控制体内特定位置热敏脂质体的药物释放。本文对高强度聚焦超声在药物控制释放领域的应用及进展进行综述。

Progress and Application of High-intensity Focused Ultrasound in Controlled Drug Delivery

High-intensity focused ultrasound (HIFU) can effectively penetrate deep into the interior of the body and be focused in a small spatial region in deep tissue in a noninvasive way, leading to high levels of acoustic energy, which is absorbed by the tissue resulting in local temperature increase. When the temperature reaches the phase transition melting temperature (Tm) of the liposomal bilayer, the alkyl chains of the phospholipids will experience a conformational change, leading to an increase in the permeability of the lipid bilayer, resulting in liposomal drug release Therefore, HIFU can be used as an external stimulus for local drug release from thermosensitive liposomes (TSL) at the desired location within the body. This review gives an overview of the application and progress of HIFU in drug delivery areas.