盐酸戊乙奎醚治疗有机磷中毒重度中间综合症临床研究

目的:探讨分析盐酸戊乙奎醚在急性有机磷中毒重度中间综合症治疗中的效果。方法:选取急性有机磷中毒并发重度中间综合症患者34例,依治疗方案分为对照组和观察组,各17例。2组患者基础治疗相同,对照组给予氯解磷定+阿托品+机械通气治疗;观察组采用氯解磷定+盐酸戊乙奎醚+机械通气治疗。观察比较2组患者肌无力症状消失时间、机械通气时间以及住院时间。结果:观察组患者肌无力症状消失时间、机械通气时间以及住院时间均明显低于对照组,经比较,差异均有统计学意义(P0.01)。结论:盐酸戊乙奎醚可快速有效缓解急性有机磷中毒重度中间综合症患者的临床症状,显著缩短病程。

Clinical Study of Penehyclidine Hydrochloride in the Treatment of Severe Organic PhosPhorus Poisoning Intermediate Syndrome

Objective:By analyzing the acute severe organic PhosPhorus Poisoning Intermediate syndrome to acquaintance the treatment about the efficacy of Penehyclidine hydrochloride.Methods:34 cases of acute organic PhosPhorus Poisoning Intermediate syndrome were selected and divided into the control group and the therapeutic group. Each group had 1 7 cases and based on the same treatment. Patients in the control group were treated with Pralidoxime Chloride + Atropine + Mechanical ventilation, and in the therapeutic group were treated with Pralidoxime Chloride + Penehyclidine Hydrochloride + Mechanical ventilation. The length of myasthenia lasting, mechanical ventilation using and the hospital stay were observed and compared.Results:The length of myasthenia lasting, mechanical ventilation using and the hospital stay in the therapeutic group was much shorter than the observations in control group (P<0.01).Conclusion:Penehyclidine Hydrochloride can effectively alleviate the symptom of acute severe organic Phosphorus Poisoning Intermediate syndrome fast and shorten the course of disease greatly.