心房颤动并发血栓栓塞患者脑钠肽与D-二聚体的表达及相关性分析

目的:观察房颤及房颤并发血栓栓塞患者血浆内脑钠肽(brain natriuretic peptide,BNP)和D-二聚体(D-dimer)的表达水平;探讨两者表达水平的关联性以及两者对房颤血栓栓塞的预测价值。方法:回顾分析2010年5月-2012年12月上海市第一人民医院心内科住院病人;根据入组及排除标准将符合条件的研究对象74例分为对照组、单纯房颤组与房颤血栓组;对所有对象进行数据采集,包括年龄、性别、血脂情况、高血压病史、血糖等情况;对所有对象进行D-dimer及BNP水平的数据采集。结果:(1)房颤血栓组的年龄明显高于对照组(P0.01)和单纯房颤组(P0.001);(2)房颤血栓组的D-dimer和BNP水平高于单纯房颤组(P0.05)和对照组(P0.001);(3)单纯房颤组BNP水平与D-dimer水平呈正相关性(r=0.507,P=0.004),房颤血栓组BNP水平与D-dimer水平呈正相关性(r=0.680,P0.001)。结论:(1)心房颤动患者随着年龄的增加并发血栓栓塞风险也增加,指导我们在临床治疗时需要重视年龄因素。(2)患者血浆中D-dimer和BNP水平的增高是心房颤动并发血栓栓塞患者的危险信号。(3)D-dimer和BNP检测在预防心房颤动并发血栓栓塞中有重要的临床意义。

Correlation of Brain Natriuretic Peptide with D-dimer in Patients with Atrial Fibrillation

Objective:To observe the level of brain natriuretic peptide (BNP) and D-dimer in patients with atrial fibrillation (AF) and its thromboembolic complication; To elucidate the relationship between BNP, D-dimer and embolism complication in patients with atrial fibrillation.Methods:Seventy-four patients were selected from patients in Department of Cardiology in Shanghai First People''s Hospital from May 2010 to December 201 2. They were divided into control group, AF group and thrombosis group according to inclusion and exclusion criteria. We collected data on all selected patients of age, gender, history of hypertension, blood lipid and blood glucose. We also reviewed level of D-dimer and BNP of these patients.Results:(1 ) The patients in thrombosis group were older than control group (P<0.01 ) and AF group (P<0.001 ). (2) Levels of D-dimer and BNP were higher in thrombosis group than control group (P<0.05) and AF group (P<0.001 ). (3) There was positive correlation between BNP and D-dimer in AF group (r=0.507, P=0.004) and in thrombosis group (r=0.680, P<0.001 ).Conclusion:(1) The risk of thromboembolism is related to age of AF patients. (2) Increased levels of D-dimer and BNP in plasma is a dangerous signal of patients with thromboembolism. (3) D-dimer and BNP detection has important clinical significance in preventing atrial fibrillation complicated with thromboembolism.