孟鲁司特纳片联合沙美特罗替卡松粉吸入剂对儿童支气管哮喘的临床疗效

目的:探究孟鲁司特纳片联合沙美特罗替卡松粉吸入剂治疗儿童支气管哮喘的临床疗效并分析复发情况。方法:选取2011年9月至2012年12月在本院就诊并住院治疗的100例支气管哮喘患儿,随机分成的对照组以及研究组,各50例。对照组吸入沙美特罗替卡松粉吸入剂,研究组给予孟鲁司特纳片联用沙美特罗替卡松粉吸入剂,观察哮喘的复发和控制情况。结果:用药治疗后两组肺功能指标均有改善(P<0.05);研究组用药第3、6个月和停药6个月时患儿肺功能较对照组改善更明显,差异均有统计学意义(P<0.05);两组患儿治疗后临床控制率均有显著的改善,但仅研究组差异有统计学意义(P<0.05);研究组在用药3个月、6个月以及停药6个月三个阶段临床控制率均高于对照组,而在用药6个月以及停药6个月两个阶段复发率均低于对照组,差异均有统计学意义(P<0.05)。结论:孟鲁司特纳片联合沙美特罗替卡松粉吸入剂治疗儿童支气管哮喘疗效较单用沙美特罗替卡松粉吸入剂治疗效果更好,复发率低。

Efficacy of Montelukast Sodiumand SALMETEROL Fluticasone Powder Inhalation on Childhood Bronchial Asthma

Objective:To explore the efficacy and recurrence of Montelukast Sodium and SALMETEROL Fluticasone Powder Inhalation on childhood bronchial asthma.MethodsSelected 100 cases of children bronchial asthma from Sep,2011 to Dec, 2012 in our hospital,which were randomly divided into two groups: control group and study group, 50 cases in each.The control group were taken SALMETEROL Fluticasone Powder Inhalation for 6 months, while the study group were taken Montelukast Sodiumand SALMETEROL Fluticasone Powder Inhalation. observed the recurrence and control of asthma.Results: Two groups of indices of pulmonary function were improved after drug treatment. The lung function of study group was obviously improved than control group by 3 months, 6 months,and 6 months after discontinuation, the differences were statistically significant (P<0.05); The clinical control rates have improved significantly in two groups,but only the study group had significant difference(P<0.05). The clinical control rate of study group was higher than that of control group by 3 months, 6 months, and 6 months after discontinuation, and the recurrence rate was significantly lower than the control group by 6 months, and 6 months after discontinuation (P<0.05), the differences were statistically significant (P<0.05).Conclusion:Montelukast Sodiumand SALMETEROL Fluticasone Powder Inhalation on childhood bronchial asthma have obvious curative effect and low recurrence rate than treated with SALMETEROL Fluticasone Powder Inhalation alone.