| 犬获得性食管气管瘘模型建立及食管双瓣修补术实验研究 |
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| 引用本文： | 白光振,杨光,韩勇,汪健,李小飞,周勇安,赵芳,程庆书.犬获得性食管气管瘘模型建立及食管双瓣修补术实验研究[J].现代生物医学进展,2010,10(1). |
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| 作者姓名： | 白光振 杨光 韩勇 汪健 李小飞 周勇安 赵芳 程庆书 |
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| 作者单位： | 第四军医大学唐都医院胸腔外科,陕西,西安,710038 |
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| 摘 要： | 目的:1.建立犬食管气管瘘动物模型;2.观察食管壁双瓣修补气管缺损术局部组织病理学改变、愈合情况及该术式的治疗效果。方法:犬16只,随机分为2组,实验组(12只)建立犬食管气管瘘动物模型,行食管壁双瓣修补气管缺损术,对照组(4只)正常犬作为空白对照,术后支气管镜检查,术后1,2,8周处死动物,观察实验动物一般情况、修补局部的大体改变和组织病理学改变,测定气管狭窄指数。结果:成功建立了犬食管气管瘘动物模型;食管双瓣修补术后,实验组动物呛咳症状消失,均存活至预定时间,修补瓣和气管之间愈合良好,修补瓣血供良好,未出现气管狭窄情况,气管通畅度良好。结论:通过手术方式建立食管气管瘘模型方法可靠;食管双瓣修补术治疗TEF效果良好,值得进一步研究及推广。
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| 关 键 词： | 食管气管瘘 模型 食管 修补 气管 缺损 |
Establishment of Canine Tracheoesophageal Fistula Model and Experimental Study of Esophageal Double Patch Repair |
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| BAI Guang-zhen,YANG Guang,HAN Yong,WANG Jian,LI Xiao-fei,ZHOU Yong-an,ZHAO Fang,CHENG Qing-shu.Establishment of Canine Tracheoesophageal Fistula Model and Experimental Study of Esophageal Double Patch Repair[J].Progress in Modern Biomedicine,2010,10(1). |
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| Authors: | BAI Guang-zhen YANG Guang HAN Yong WANG Jian LI Xiao-fei ZHOU Yong-an ZHAO Fang CHENG Qing-shu |
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| Institution: | BAI Guang-zhen,YANG Guang,HAN Yong,WANG Jian,LI Xiao-fei,ZHOU Yong-an,ZHAO Fang,CHENG Qing-shu(Department of Thoracic Ssurgery,Tangdu Hospital,Fourth Military Medical University,Xi\'an 710038,China) |
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| Abstract: | Objective:1.To establish the canine model of tracheoesophageal fistula;2.To observe the pathological changes and healing process of the anastomosis between the patch and trachea and the effect of esophageal double patch repairing tracheal defects.Methods:16 dogs were randomly divided into 2 groups.Experimental group(12 dogs) were used to establish the tracheoesophageal fistula model and implement esophageal double patch repairing tracheal defects.Control group(4 dogs) were as a blank control with no treatme... |
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| Keywords: | Tracheoesophageal fistula Model Esophagus Repair Trachea Defect |
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