MMP-2、MMP-7、MMP-9、TIMP-1及TIMP-2在乳腺癌组织中的表达及意义

目的:探讨基质金属蛋白酶及其抑制剂在乳腺癌组织中的表达及其与肿瘤浸润转移的关系,为乳腺癌的临床治疗及预后预测提供基础。方法:选择我院2012年5月至2014年5月收治的乳腺癌患者80例,对所选病例的乳腺癌组织、癌旁组织及正常乳腺组织样本进行检测。观察并比较不同乳腺组织中MMP-2,MMP-7、MMP-9、TIMP-1及TIMP-2 m RNA的表达水平。结果:与正常乳腺组织相比较,乳腺癌组织和癌旁组织中MMP-2、MMP-7、MMP-9,TIMP-1及TIMP-2 m RNA的表达显著增加,差异具有统计学意义(P0.05)。乳腺癌组织中MMP-2、MMP-7、MMP-9、TIMP-1及TIMP-2 m RNA的表达显著高于癌旁组织和正常组织,差异具有统计学意义(P0.05)。随着肿瘤范围扩大,MMP-2、MMP-7和MMP-9 m RNA的表达水平显著增加(P0.05),而TIMP-1和TIMP-2 m RNA表达无显著变化(P0.05)。随着淋巴结转移进展,MMP-2、MMP-7和MMP-9 m RNA的表达显著增加(P0.05),而TIMP-1和TIMP-2 m RNA无显著变化(P0.05)。结论:MMP-2、MMP-7、MMP-9、TIMP-1和TIMP-2的m RNA在乳腺癌组织中呈高表达,这可能与乳腺癌的发生和发展有关,而MMP-2、MMP-7和MMP-9可能有助于预测乳腺癌的侵袭行为。

Expressions and Significances of MMP-2, MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNAs in the Breast Cancer

Objective:To explore the expressions of MMPS and TIMPs in the tissues of breast cancer and their relationships with tumor metastasis in order to provide references for the treatment and prognostic prediction of breast cancer.Methods:80 patients with breast cancer who were treated in our hospital from May 2012 to May 2014 were selected. Then the mRNA expressions of MMP 2, MMP-7, MMP-9, TIMP 1 and TIMP-2 in breast cancer, para-carcinoma tissue and normal breast tissues were detected and compared.Results:Compared with that in the normal breast tissues, the mRNA expressions of MMP 2, MMP-7, MMP-9, TIMP 1 and TIMP-2 in the breast cancer and para-carcinoma tissue were all significantly increased (P<0.05). The mRNA expressions of MMP 2, MMP-7, MMP-9, TIMP-1 and TIMP-2 in the breast cancer tissues and the para-carcinoma tissue were significantly higher than those of the control group(P<0.05). With the increase of tumor range, the mRNA expression of MMP-2, MMP-7 and MMP-9 were all significantly increased (P<0.05), and no significant difference was found in the mRNA expression of TIMP-1 and TIMP-2 (P>0.05). With the progression of lymph node metastasis, the mRNA expressions of MMP-2, MMP-7 and MMP-9 were all significantly increased (P<0.05), and no significant difference was found in the mRNA expression of TIMP-1 and TIMP-2 (P>0.05).Conclusion:MMP 2, MMP-7, MMP-9 and TIMP 1 and TIMP-2 mRNA were highly expressed in breast cancer tissue, which could be closely related to the occurrence and development of breast cancer. MMP 2, MMP-7 and MMP-9 may be useful for the prediction of infiltration and metastasis of breast cancer.