PCT和NT-proBNP在脓毒血症患者生存状况预测中的应用与评价

目的:探究患者降钙素原(PCT)和N端前体脑利钠肽(NT-proBNP)水平在评价脓毒血症患者生存状况的预测价值。方法:本研究于2013年6月~2015年6月期间,选择在我院治疗的脓毒血症患者81例为研究对象,根据患者纳入研究后1个月的生存状况,将所有研究对象分为存活组(55例)和死亡组(26例)。分别测定患者PCT和NT-proBNP水平,并记录患者急性生理与慢性健康状况(APACHEII)评分,通过ROC曲线探究PCT、NT-proBNP对患者生存预后评估的价值。结果:死亡组患者PCT水平及APACHEII评分均显著高于存活组,NT-pro BNP水平显著低于存活组患者(P0.05);PCT与APACHEII评分存在正相关关系(r=0.311;P0.05);NT-pro BNP水平与APACHEII评分存在负相关关系(r=-0.289;P0.05);ROC曲线显示PCT、NT-proBNP水平预测患者生存状况的敏感性(86.23%、82.01%)及特异性(80.89%、87.39%)均较高。结论:脓毒血症患者血清PCT与NT-proBNP水平在预测患者病情严重程度及生存状况方面具有重要价值。

Application and Aalue of PCT and NT-proBNP on Forecasting the Survival Condition in Patients with Sepsis

Objective:To explore the value of procalcitonin (PCT) and n-terminal pro-brain natriuretic peptide (NT-proBNP) on forecasting the survival condition in patients with sepsis.Methods:81 cases of patients with sepsis were treated in our hospital from June 2013 to June 2015 were selected as research objects, who were divided into survival group (n=55) and death group (n=26) according to the survival condition one month after the research started. Detected the levels of PCT and NT-pro BNP, and recorded the acute physiology and chronic health conditions (APACHEII) score of two groups, and evaluated the value of PCT and NT-proBNP on forecasting the survival condition in patients with sepsis through receiver operating characteristic(ROC) curve.Results:The level of PCT and APACHEII score in death group were significant higher than survival group, and the level of NT-proBNP in death group were significant lower than survival group (P<0.05); The level of PCT was positively correlated with APACHEII score (r=0.311, P<0.05), and the level of NT-proBNP was negatively correlated with APACHEII score(r = -0.289; P<0.05); ROC curves showed that the level of PCT, NT-proBNP had high sensitivity(86.23%, 82.01%) and specificity(80.89%, 87.39%) on forecasting the survival condition in patients with sepsis.Conclusion:The level of PCT and NT-proBNP plays an important role on forecasting the severity of illness and survival condition in patients with sepsis.