SSTR-2、E-cad与不明原因的反复自然流产相关性研究

目的:研究生长抑素2型受体(SSTR2)、E-钙粘附素(E-cad)与不明原因的反复自然流产相关性。方法:选取2011年1月到2014年12月我院收治的不明原因反复自然流产患者60例(研究组),另选同期早期正常孕妇且准备流产者60例(对照组),应用免疫组化技术检测两组蜕膜组织中的SSTR2和E-cad表达,并进行比较。结果:研究组蜕膜组织中SSTR-2阳性细胞平均光密度显著高于对照组,而E-cad阳性细胞平均光密度显著低于对照组,两组比较差异具有统计学意义(P0.05);研究组蜕膜组织中SSTR-2与E-cad水平呈负相关关系,对照组蜕膜组织中SSTR-2与E-cad水平呈正相关关系(P0.05)。结论:蜕膜组织中SSTR-2高表达与E-cad低表达可能与不明原因的反复自然流产有关。

Correlation between SSTR-2, E-cad and Unexplained Recurrent Spontaneous Abortion

Objective:To study the correlation between somatostatin receptor type 2 (SSTR-2), E-cadherin (E-cad) and unexplained recurrent spontaneous abortion.Methods:Selected 60 patients with unexplained recurrent spontaneous abortion from our hospital from January 2011 to December 2014 (as study group), and another 60 early normal pregnant who prepared to abort from the same period (as control group), then detected and compared the expression level of SSTR2 and E-cad in deciduas of two groups by immunohistochemistry method.Results:SSTR-2 positive cell mean optical density in study group was significantly higher than control group, but the E-cad positive cell mean optical density was significantly lower than control group, the differences were statistically significant (P<0.05); Expression level of SSTR-2 was negatively correlated with E-cad in deciduas of study group, while the expression level of SSTR-2 was positively correlated with and E-cad in deciduas of control group (P<0.05).Conclusion:High expression of SSTR-2 and Low expression of E-cad in deciduas may be correlated with unexplained recurrent spontaneous abortion.