缺血性脑血管病患者血清MMP-8和IL-6水平与颈动脉粥样硬化的关系

目的：分析缺血性脑血管病患者血清MMP-8 和IL-6 的表达水平与颈动脉粥样硬化斑块稳定性的关系。方法：选取2013 年5 月至2014 年10 月我院收治的80 例缺血性脑血管病患者作为研究组，另选取同期在我院门诊接受体检的80 例健康人群作为对 照组。采用双抗体夹心酶联免疫吸附试验(ELISA)检测两组研究对象血清MMP-8 和IL-6 水平。利用Spearman 等级相关性分析方 法分析缺血性脑血管病患者颈动脉斑块的稳定程度与血清MMP-8和IL-6 水平的关系。结果：研究组缺血性脑血管病患者血清中 MMP-8 和IL-6 水平明显高于对照组，两组间数据差异存在统计学意义（P<0.01）。研究组患者中不稳定斑块28 例，稳定斑块32 例，斑块类型介于中间20 例。不稳定斑块患者血清MMP-8 和IL-6 水平高于中间斑块和稳定斑块患者，中间斑块患者血清 MMP-8 和IL-6 水平高于稳定斑块患者，组间比较，差异均具有统计学意义（P<0.05）。Spearman 等级相关性分析结果显示，缺血性 脑血管病患者颈动脉斑块的稳定程度与血清MMP-8 和IL-6 水平存在显著的正相关关系（r=0.71，0.66；P<0.05）。结论：缺血性脑 血管病患者血清MMP-8 和IL-6 水平与颈动脉斑块稳定程度相关。

Relationship between Expression of SerumLevels of MMP-8, IL-6 and Carotid Atherosclerotic Plaques of Patients with Ischemic Cerebrovascular Disease

Objective:To observe the levels of MMP-8 and IL-6 in serum of patients with ischemic cerebrovascular disease, and relationship with the carotid atherosclerotic plaques.Methods:80 patients with ischemic cerebrovascular disease were selected as the study group, and another 80 healthy people who had taken the examination in our hospital fromMay 2013 to October 2014 were choosen as the control group. Then the levels of MMP-8 and IL-6 in serum of patients in the two groups were detected by the ELISA method, and the ralationship of MMP-8 and IL-6 with the ischemic cerebrovascular disease were analyzed by the Spearman rank correlation analysis method.Results:Compared with control group, serumlevels of MMP - 8, IL - 6 were higher, differences was statistically significant (t = 15.762, 37.145, P=0.000< 0.01); there was significant difference between groups for Patients with three different types of levels of plaque MMP-8, IL-6 in serum (F=21.146, 221.853, P= 21.146<0.01); Team in patients with carotid artery plaque stability and serum levels of MMP - 8, concentration of IL-6 Spearman rank correlation analysis,there was significant positive relationship (r=0.71, 0.66, P< 0.01).Conclusion:The serum MMP-8 and IL-6 of ischemic cerebrovascular disease increased significantly, it associate with the degree of carotid artery plaque instability, also associate with the pathogenesis of ischemic cerebrovascular disease for synergy.