乌司他丁联合痰清宁雾化吸入对重症肺炎患者肌钙蛋白水平及心肌酶谱的影响

目的:探讨乌司他丁联合痰清宁雾化吸入对重症肺炎患者肌钙蛋白水平、心肌酶谱的影响。方法:收集2014年3月至2016年3月于我院治疗的104例重症肺炎患者,52例行常规治疗患者作为对照组,52例于常规治疗基础上行乌司他丁联合痰清宁雾化吸入患者作为观察组,比较两组体征及症状消失时间、肌钙蛋白心肌肌钙蛋白T(cTnT)、心肌肌钙蛋白I(cTnI)]、心肌酶谱谷草转氨酶(AST)、乳酸脱氢酶(LDH)\氢丁酸脱氢酶(HBDH)、肌酸激酶同工酶(CK-MB)]、临床症状积分、临床疗效及不良反应的发生情况。结果:观察组体征及症状消失时间明显短对照组(P0.05);治疗后,观察组cTnT、cTnI低于对照组,差异有统计学意义(P0.05);观察组AST、LDH、HBDH、CK-CB低于对照组,差异有统计学意义(P0.05);观察组临床症状积分低于对照组(P0.05);观察组有效率96.15%高于对照组82.69%(P0.05);两组不良反应发生率比较无统计学差异(P0.05)。结论:乌司他丁联合痰清宁雾化吸入治疗重症肺炎的临床疗效好,且可有效降低肌钙蛋白及心肌酶谱水平,减轻心肌损伤。

The Influence of Ulinastatin Combined with Tanqingning Aerosol Inhalation on the Troponin Levels and Myocardial Enzyme Spectrum of Patients with Severe Pneumonia

ABSTRACT Objective: To study the influence of ulinastatin combined with phlegm qing ning aerosol inhalation on the troponin levels and myocardial enzyme spectrum of patients with severe pneumonia. Methods: 104 cases of patients with severe pneumonia from March 2014 to March 2016 were collected in our hospital, 52 cases with routine treatmented as control group, 52 cases with the conven- tional treatmented based uplink ulinastatin combined phlegm qing ning aerosol inhalation were selected as the observation group, the signs and symptoms disappearance time, troponin myocardial troponin T (cTnT), cardiac troponin I (cTnI)], myocardial enzyme spec- trum aspertate aminotransferase (AST), lactate dehydrogenase (LDH), hydrogen butyric acid dehydrogenase (HBDH), creatine kinase isoenzyme (CK-MB)], clinical symptoms integral ,clinical efficacy and adverse reaction of two groups were compared. Results: The signs and symp- toms disappearance time of observation group of was shorter than that of control group(P<0.05). After treatment, the cTnT and cTnI levels of observation group were lower than the those of control group (P<0.05); the AST, LDH, HBDH and CK-MB levels of ob- servation group were lower than those of the control group (P<0.05); The clinical symptom score of the observation group was lower than that of the control group (P<0.05); The effective rate of observation group was 96.15%, which was higher than 96.15% of the control group (P<0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Ulinastatin combined with sputum qing ning aerosol inhalation therapy have good clinical curative effect on severe pneumonia, which could reduce the troponin and myocardial enzyme levels, improve the myocardial injury.