α1-肾上腺素受体介导交感神经对机体调节及针灸效应的研究情况分析

为明确近30年α_1-AR(a1-Adrenoceptor)介导交感神经对机体生理病理变化及针灸效应的研究情况,本文查阅CNKI数据库及Pubmed数据库,对近30年关于α_1-AR介导的交感神经对机体生理病理影响及针灸效应的研究情况进行系统回顾。发现α_1-AR不但介导交感神经对心脏的变力变时效应,以及血管平滑肌、膀胱括约肌和子宫平滑肌的收缩等生理效应的调节,还介导了心律失常、心肌肥大等病理过程,此外,α_1-AR还介导了针刺信号的传导,而且针刺还可以调节交感神经张力。说明机体的许多生理病理改变与α_1-AR及亚型的变化有密切关系,因此,深入研究α_1-AR将有助于阐释机体的生理病理机制,也为有效药物提供理论依据和相应的药理模型;对经脉穴位上α_1-AR的深入研究,有助于经络实质的探讨及针刺效应物质基础研究。

Analysis Regarding Effect of Sympathetic Nerves on Body Regulation and Acupuncture Efficacy by Alpha1-adrenoreceptor Mediation

ABSTRACT: To clarify the effect of the sympathetic nerves on the body''s physiopathological changes and acupuncture effect by the alphal-AR mediation in the past 30 years. The paper has referred to the database of CNKI and Pubmed, and systematically reviewed the publications in the past 30 years about the research of the alpha1-AR mediation of the sympathetic nerves to the body''s physiological and pathological changes and acupuncture effect. Alphal-AR not only mediated the sympathetic nerves on the inotropic change of the heart, and the contraction of the vascular smooth muscles, bladder sphincter, and uterine smooth muscles and other physiological effect, but also mediated cardiac arrhythmia, myocardial hypertrophy and other pathological process. In addition, Alpha1-AR also mediated the acupunc- ture signal transmission, and acupuncture was able to adjust the sympathetic nervous tension. The body''s physiopathological changes are closely related to alpha1-AR and subtype alteration. The in-depth study of alpha1-AR helps to explain physiopathological mechanism of the body, as well as provide theoretical basis and the corresponding pharmacological models for better selective drugs. Studying Al- pha1-AR on meridians contributes to the discovery of meridian essence and the substantial basis of acupuncture effects.