谷氨酰胺对胃大部切除患者血清胃泌素、CA72-4及HIF-1α水平的影响

目的:探究谷氨酰胺对胃大部切除患者术后血清胃泌素、CA72-4及HIF-1α水平影响。方法:收集我院56例胃大部切除术后患者,随机分为实验组和对照组,各28例。对照组给予临床常规营养治疗,实验组在对照组基础上给予丙氨酰谷氨酰胺注射液100 m L/d。治疗结束后,比较两组患者临床疗效血清胃泌素、CA72-4、HIF-1α及VEGF-A水平。结果:对照组患者治疗后临床有效率71.43%低于研究组患者治疗后临床有效率92.86%,具有统计学意义(P0.05);对照组患者复发率35.71%明显高于实验组10.71%,具有统计学意义(P0.05)。治疗后与治疗前相比,患者血清胃泌素、CA72-4、HIF-1α及VEGF-A水平均降低(P0.05);与对照组比较,实验组血清胃泌素、CA72-4、HIF-1α及VEGF-A水平较低(P0.05)。结论:谷氨酰胺能有效提高胃大部切除患者术后的临床疗效,防止复发,推测其机制与降低血清胃泌素、CA72-4、HIF-1α及VEGF-A水平有关。

Effect of Glutamine on the Serum Levels of Gastrin, CA72-4 and HIF-1a in Patients with Subtotal Gastrectomy

ABSTRACT Objective: To investigate the effect of glutamine on the serum gastrin, CA72-4 and HIF-1a levels in patients with subtotal gastrectomy. Methods: A total of 56 patients with subtotal gastrectomy from our hospital were collected and randomly divided into experimental group and control group with 28 cases in each group. The patients in the control group were treated by clinical routine nutrition therapy, and the patients in the experimental group were treated on the base of the control group with alanyl glutamine injection 100 mL/d. After treatment, the clinical curative effect, the serum level of gastrin, CA72-4, HIF-1a and VEGF-A in the two groups was compared. Results: Compared with before treatment, the serum gastrin, CA72-4, HIF-1a and VEGF-A levels were lower after treatment (P<0.05); Compared with the control group, the serum gastrin, CA72-4, HIF-1a and VEGF-A levels were lower in experimental group (P<0.05). Conclusion: Glutamine has good clinical efficacy on the prevention of recurrence of subtotal gastrectomy, and its mechanism might be related to reduction of the serum gastrin, CA72-4, HIF-1a and VEGF-A levels.