兰索拉唑与奥美拉唑对胃溃疡患者氧化应激水平和内皮功能的影响

目的:探讨兰索拉唑(LAN)与奥美拉唑(OME)治疗胃溃疡的临床效果及对患者血浆氧化应激水平和血管内皮功能的影响。方法:选取我院2014年1月~2016年10月收治的138例胃溃疡患者,按照随机数字表法均分为LAN组和OME组,并选取我院同期69例健康体检者为对照组。对照组不用任何药物,LAN组予以LAN治疗,OME组给予OME治疗。记录比较LAN组和OME组的临床疗效、Hp根除率及胃镜疗效;对照组与LAN组、OME组两组治疗前后血浆氧化应激指标、血管内皮功能指标水平;并评价LAN组与OME组的用药安全性。结果:总疗程结束后,LAN组总有效率、Hp根除率分别为94.2%、89.9%,较OME组(91.3%、87.0%)相比差异无统计学意义(P0.05)。经4个疗程后,LAN组胃镜总有效率为95.7%,明显高于OME组的85.5%(P0.05)。与对照组相比,LAN组、OME组治疗前血浆MDA、ET-1水平均显著上升(P0.01),SOD、NO水平均显著降低(P0.01)。与本组治疗前对比,LAN组、OME组治疗后血浆MDA、SOD、NO及ET-1水平均显著改善(P0.01),且LAN组治疗后各血浆因子水平改善效果均显著优于OME组(P0.01)。结论:LAN治疗胃溃疡改善患者临床症状、根除Hp的效果及安全性与OME相当,但LAN更能有效降低机体的氧化应激水平,调节血管内皮功能,促进溃疡愈合。

Effects of Lansoprazole and Omeprazole on the Oxidative Stress and Endothelial Function of Gastric Ulcer Patients

ABSTRACT Objective: To explore the clinical efficacy of lansoprazole (LAN) and omeprazole (OME) in the treatment of gastric ul- cer and its effect on the oxidative stress and endothelial function. Methods: 138 cases with gastric ulcer in our hospital from January 2014 to October 2016 were selected and randomly divided into the LAN group and the OME group. 69 healthy cases who received physical check in our hospital at same period were selected as the control group. The LAN group and OME group were treated by LAN and OME respectively. The clinical effect, Hp eradication rate and gastroscopy effect were compared. Compare with the control group, the plasma oxidative stress and vascular endothelial index of LAN group and OME group were analyzed before and after therapy, the incidence of adverse reactions were compared between LAN group and OME group. Results: After treatment, the effectiveness rate and Hp eradica- tion rate of LAN group were 94.2% and 89.9% respectively, which were 91.3%, 87.0% in the OME group, no statistical difference was found between the two groups(P>0.05). At the end of 4th therapy peroid, the gastroscopy overall effectiveness rate of LAN group was 95.7%, which was significant higher than that of the OME group(85.5%, P<0.05). The plasma MDA, ET-1 levels were significantly in- creased of LAN group and OME group compared with those data of the control group(P<0.01), the SOD, NO levels were significantly decrease compared with those data of the control group (P<0.01). all plasma factors improved better in the LAN group than those of OME group after treatment(P<0.01). There was no statistical significance in the incidence of adverse reactions between LAN group(8.7%) and OME group(10.1%)(P>0.05). Conclusion: LAN had similar effect and safety to OME in improving patient''s clinical symp- toms, eliminating Hp, but LAN was more effectively to balance body''s oxidation/antioxidant capacity, regulate the vascular endothelial function, promote the ulcer healing.