原发性高血压相关基因DNA甲基化的研究进展

高血压是常见的慢性疾病,也是心脑血管病最主要的风险因素。原发性高血压是由多基因和环境因素共同作用引起的复杂疾病,但具体的发病机制仍不清楚。随着研究的深入,DNA甲基化等表观遗传学因素在原发性高血压病理过程中起到的作用逐渐受到重视。本文总结了部分原发性高血压关联基因中DNA甲基化在其患病中的研究进展,阐述可受环境因素影响的DNA甲基标记与原发性高血压的关系,进一步了解高血压的发病机制。

The Research Progress of Essential Hypertension Related Gene DNA Methylation

ABSTRACT: Hypertension is a common and chronic disease, and is also the mainly risk factor of cardio-cerebrovascular disease. Essential hypertension is a complex disease caused by the common function of multiple genes and environmental factors, but the exact pathogenesis is still unclear. With the study continues, the role of DNA methylation and other epigenetic factors in pathological process with essential hypertension (EH) gradually be taken seriously. This review summarizes the research progress of some essential hypertension related methylation genes'' function in the course of hypertension, to explain the relationship between DNA methylation markers which can be influenced by environment factor and essential hypertension and help us have a further understanding about the hypertension pathogenesis.