神经血管单元和Notch信号通路在缺血性卒中后的作用

缺血性卒中是临床常见疾病,且致死致残率高,幸存的患者预后多不同程度的患有偏瘫等后遗症,但目前还没有好的治疗方法。很长一段时间以来,卒中后的治疗关注点在于神经元的保护,割裂了神经元和周围细胞的联系。2001年,"神经血管单元"概念的提出为缺血性卒中的临床治疗提供了新的角度。此外,有研究表明Notch信号通路参与了神经、血管再生过程,对于卒中后神经血管单元的修复有调节作用。因此,本文从神经血管单元和Notch信号通路两个切入点综述了二者在缺血性卒中发生后的作用。

The Role of Neurovascular Unit and Notch Signaling Pathways in Ischemic Stroke

ABSTRACT: Ischemic stroke is a kind of clinical common diseases, which had high disability rate and high fatality rate. The surviving patient prognosis is poor, more with varying degrees of hemiplegia sequelae, but there is no good treatment. For a long time, the treatment of stroke is focused on the protection of neurons, cutting up the relationship of neurons and the surrounding cells. Until 2001, the concept of neurovascular unit (NVU) offers a new perspective for the clinical treatment of ischemic stroke. And studies have shown that Notch signaling pathways are involved in the process of nerve and vascular regeneration, namely Notch signaling pathways adjust the repair of NVU after stroke. So the action of NVU and the Notch signal pathway after ischemic stroke was reviewed in this article.