血常规在头颈部鳞状细胞癌早期诊断中的作用

目的:探究血常规指标在头颈部鳞状细胞癌早期诊断中的作用,从血液学的角度为头颈部鳞状细胞癌的早期诊断提供参考依据。方法:对181例头颈部良恶性肿瘤患者的血常规结果进行回顾性分析,比较头颈部鳞状细胞癌患者组(实验组)和头颈部良性肿瘤组(对照组)患者的血小板计数(PLT)、血小板比积(PCT)、血小板平均容积(MPV)、血小板分布宽度(PDW)、大血小板比率(P-LCR)、中性粒细胞计数(NEU)、淋巴细胞计数(LYM)、单核细胞计数(MONO)、嗜酸性粒细胞计数(EOS)、嗜碱性粒细胞计数(BASO)、血小板计数/淋巴细胞计数比值(PLR)以及中性粒细胞计数/淋巴细胞计数比值(NLR)共12个指标。结果:实验组和对照组的PLT、PCT、MPV、PDW、P-LCR以及BASO计数值比较均没有统计学差异(p0.05)。对照组NEU、MONO、EOS、PLR和NLR均低于实验组,而LYM计数值高于实验组,其差异均具有统计学意义(p0.05),ROC曲线显示NLR对于早期诊断的意义要优于PLR。结论:血小板相关指标在头颈部鳞状细胞癌早期诊断中无明显意义,白细胞亚型计数具有重要的提示作用,而NLR的诊断意义要高于PLR,或许可以联合其他鳞癌标志物进行早期诊断。

The Role of Blood Routine Examination in the Early Diagnosis of Head and Neck Squamous Cell Carcinoma

ABSTRACT Objective: To investigate the role of routine blood indexes in the early diagnosis of head and neck squamous cell carcinoma (HNSCC), and provide references from hematology. Methods: 181 cases of head and neck benign and malignant tumor patients were analyzed retrospectively, blood platelet count(PLT), platelet crit(PCT), mean platelet volume(MPV), platelet distribution width(PDW), platelet larger cell ratio(P-LCR), neutrophil count(NEU), lymphocyte count(LYM), monocyte count (MONO), eosinophil count (EOS), basophil count (BASO), platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) were compared between HNSCC (experimental group) and head and neck benign tumor patients (control group). Results: There was no statistic difference in the PLT, PCT, MPV, PDW, P-LCR and BASO between control group and experimental group (p>0.05), NEU, MONO,EOS, PLR and NLR in control group were lower than those in the experimental group with higher LYM (p<0.05), the ROC curve showed that the significance of NLR was better than PLR for the early diagnosis of HNSCC. Conclusion: In the early diagnosis of HNSCC, the platelet parameters had no significance but white blood cell parameters significant implication. The diagnostic value of NLR was better than PLR, it might be used for early diagnosis combined with some other squamous carcinoma markers.