益气养阴活血化瘀方对心力衰竭合并房颤患者血清CRP，BNP，CK-MB及cTnI水平的影响及其疗效观察

目的:探讨益气养阴活血化瘀方治疗心力衰竭合并房颤的临床疗效。方法:收集2014年3月-2015年9月我院收治的158例充血性心力衰竭合并房颤的患者158例为研究对象,随机分为对照组和实验组,每组79例。对照组患者采取常规治疗,实验组患者采用益气养阴活血化瘀方治疗。观察并比较两组患者治疗前后超敏C反应蛋白(CRP)、脑钠素(BNP),CK-MB及肌钙蛋白(cTnI)水平的变化情况。结果:治疗后,与对照组相比,实验组LVEDD、LVESD明显低于对照组,而LVEF明显增高,差异具有统计学意义(P0.05);治疗后实验组患者的CK-MB、pro-BNP、cTnI及CRP水平明显低于对照组,差异具有统计学意义(P0.05)。实验组随访末期死亡率、非致死性心力衰竭及心源性休克发生率均低于对照组,差异具有统计学意义(P0.05);随访末期内建立侧支循环明显多于对照组,差异具有统计学意义(P0.05)。结论:益气养阴活血化瘀方可以有效抑制充血性心力衰竭合并房颤患者术后心脏重塑,改善左心室收缩功能,降低不良事件发生。

Clinical Effects of Yiqi Yangyin Huoxue Huayu Decoction on Serum Levels of CRP, BNP, CK-MB and cTnI in Patients with Heart Failure and Atrial Fibrillation

ABSTRACT Objective: To evaluate the clinical effects of Yiqi Yangyin Huoxue Huayu decoction on serum levels of CRP, BNP, CK-MB and cTnI in patients with heart failure and atrial fibrillation. Methods: 158 patients with heart failure and atrial fibrillation who were treated in our hospital from March 2014 to September 2015 were selected and randomly divided into the control group and the ex- periment group, with 79 cases in each group. The patients in the control group were treated with regular methods, while the patients in the experiment group were treated with Yiqi Yangyin Huoxue Huayu decoction. Then the serum levels of high-sensitivity c-reactive pro- tein (hs-CRP), brain natriuretic peptide (BNP), CK-MB and cardiac troponin-I (cTnI) of patients in the two groups were observed and compared before and after the treatment. Results: After the treatment, the LVEDD and LVESD of the experiment group were significantly lower than those of the control group, while the LVEF was significantly higher (P=0.011). The serum levels of CK-MB, pro-BNP, cTnI and hs-CRP in the experiment group were lower than those of the control group (P=0.003, 0.009). At the end of follow-up, the rate of deaths, nonfatal heart failure and regarding cardiogenic shock in the experiment group was significantly lower than those of the control group (P=0.317). Conclusion: Yiqi Yangyin Huoxue Huayu decoction has better clinical effects on the treatment of heart failure and atrial fibrillation, which can improve the malignant cardiac remodeling and left ventricular systolic function of patients, as well as reduce the incidence rates of adverse events.