香丹注射液对急性冠脉综合征患者外周血C-反应蛋白、氨基末端脑钠肽及心肌酶水平的影响

目的:探讨香丹注射液治疗急性冠脉综合征血清C-反应蛋白、氨基末端脑钠肽以及心肌酶学的影响。方法:收集我院心内科收治的急性冠脉综合征患者66例,随机分为试验组和对照组,各33例。对照组予以阿司匹林片和硫酸氢氯吡格雷片治疗,试验组在对照组基础上予以香丹注射液治疗。观察并比较两组患者的临床疗效、血清肌钙蛋白T、C-反应蛋白、氨基末端脑钠肽、心肌酶学、不良反应以及心脏事件发生情况。结果:试验组临床总有效率高于对照组(P0.05)。治疗后两组肌钙蛋白T、C反应蛋白以及氨基末端脑钠肽水平降低,且试验组低于对照组(P0.05)。治疗后两组肌酸激酶同工酶、肌酸激酶、天门冬氨酸转移酶以及乳酸脱氢酶水平降低,且试验组低于对照组(P0.05)。试验组心绞痛发作次数、心肌缺血时间以及室性早搏次数较对照组相比显著降低(P0.05)。两组不良反应比较,差异无统计学意义(P0.05)。术后1个月内试验组心脏事件发生率显著低于对照组,差异有统计学意义(P0.05)。结论:香丹注射液治疗急性冠脉综合征的疗效显著,抑制炎症反应,安全性较高,降低心脏事件发生率,适宜临床应用推广。

Effects of Xiangdan Injection on Serum Levels of C- reactive Protein, Amino Terminal Brain Natriuretic Peptide and Cardiac Enzymes of Patients with Acute Coronary Syndrome

ABSTRACT Objective: To investigate the effects of xiangdan injection on serum levels of C- reactive protein, amino terminal brain natriuretic peptide and cardiac enzymes of patients with acute coronary syndrome. Methods: 66 patients with acute coronary syndrome who were treated in our hospital were selected and randomly divided into experiment group and control group with 33 cases in each group. The patients in the control group were treated with aspirin, while the patients in the experiment group were treated with xiangdan injection. Then the clinical efficacy, the serum levels of troponin T, C- reactive protein and amino terminal brain natriuretic peptide, the cardiac enzymes, adverse reactions and cardiac events were observed and compared between the two groups before and after the treatment. Results: The total effective rate of the experiment group was higher than that of the control group (P<0.05). After treatment, the serum levels of troponin T, C - reactive protein and amino terminal brain natriuretic peptide in the two groups were lower than before, and the experiment group was lower than that of the control group (P<0.05). The serum levels of creatine kinase isoenzyme, creatine kinase, aspartate transfer enzyme and lactate dehydrogenase in the two groups were lower than before, and the experiment group was lower than that of the control group (P<0.05). The angina attacked frequency, myocardial ischemia time and ventricular premature beat frequency of the experiment group were significantly lower than those of the control group (P<0.05). There was no statistically significant difference about the adverse reactions between the two groups (P>0.05). The incidence of cardiac events rate of the experiment group was lower than that of the control group within 1 month after operation (P<0.05). Conclusion: Xiangdan injection in the treatment of acute coronary syndrome the effect is obvious, inhibition of inflammatory reaction, high safety, reduce the incidence rate of cardiac events, suitable for clinical application.