CD11b表达与人工髋关节置换术后无菌性松动的相关性分析

目的:分析髋关节周围滑膜组织CD11b表达水平与人工髋关节置换术后无菌性松动的相关性。方法:以2006年5月至2016年5月于西京医院接受人工髋关节置换的患者为研究对象,对其髋关节周围滑膜组织进行CD11b免疫组化染色,并随访术后5年和10年无菌性松动的发生情况,通过单因素分析及logistic回归分析讨论CD11b表达与无菌性松动之间的相关性。结果:共300例患者纳入研究,全部获得随访,CD11b表达阳性患者163例,阳性率为54.33%;术后5年松动患者29例,术后5年无菌性松动发生率为9.67%;术后10年无菌性松动患者49例,术后10年无菌性松动发生率为16.33%;单因素分析结果表明CD11b表达阳性患者5年及10年松动率均高于CD11b表达阴性患者(P0.05);logistic回归分析结果表明CD11b过表达是髋关节置换术后无菌性松动发生的危险因素。结论:髋关节周围滑膜组织CD11b过表达是人工髋关节置换术后无菌性松动发生的危险因素,该分子或可作为无菌性松动的辅助诊断指标及潜在治疗靶点。

Analysis of the Correlation between CD11b Expression and Aseptic Loosening

ABSTRACT Objective: To analyze the correlation between CD11b expression and aseptic loosening. Methods: CD11b of synovial tissue around the hip joint from patients received total hip replacement during 2006 May to 2016 May were immunohistochemical stained, and a follow-up was performed to detect the occurrence of aseptic loosening. Single factor analysis and logistic regression analy- sis was used to investigate the correlation between CD11b expression and aseptic loosening occurrence. Results: 300 patients were fol- lowed up; the number of CD11b positive patients was 163, CD11b postive ratio was 54.33 %; 29 patients(9.67 %) suffered from aseptic loosening 5 years after operation and 49 patients(16.33%) suffered from aseptic loosening 10 years after operation; the aseptic loosening raio of CD11b-positive patients was higher than that of CD11b-negative patients(P<0.05); logistic regression analysis suggested that CD11b over-expression was the risk factor of aseptic loosening. Conclusion: CD11b over-expression was the risk factor of aseptic loos- ening and CD11b might be an auxiliary diagnosis indicator and potential therapeutic target of aseptic loosening after total hip replace- ment.