温敏性几丁糖填充兔眼玻璃体两种手术方式对比研究

目的:通过两种手术方式对兔眼玻璃体进行温敏性几丁糖填充,比较其眼压及并发症差异。方法:将18只白兔随机分为实验组和对照组,每组各9只,右眼均为手术眼,实验组白兔行玻璃体切割术并注入温敏性几丁糖,对照组通过1 m L注射器抽取玻璃体并填充温敏性几丁糖,术后随访1月,对比两组白兔术后眼压及手术并发症的差异性。结果:实验组手术前眼压(7.76±2.21)mm Hg与术后眼压(7.49±2.98)mm Hg无明显差异(P0.05),对照组手术前眼压(7.80±2.04)mm Hg与手术后眼压(5.17±0.96)mm Hg有统计学意义(P0.05)。对照组术后并发症发生率为44.4%(4/9),明显高于实验组22.2%(2/9)。结论:玻璃体腔注射温敏性几丁糖操作简单,但并发症较多,且易造成眼压改变;而玻璃体切割术后填充温敏性几丁糖并发症相对较少,眼压波动较小,但应注意并发性白内障的发生。

The Comparison of Two Operations for Filling the Vitreous Body of Rabbits with Thermosensitive Chitosan-based Hydrogel

ABSTRACT Objective: The experiment was designed to measure the effects of two different eye operations for experimental ani- mals. Comparing the differences of the intraocular pressure and the complications of two groups of rabbits, whose vitreous body were filled with thermosensitive chitosan-based hydrogel through two different ways of operations. Methods: We divided 18 rabbits into two groups, 9 for control group and 9 for experimental group. The right eyes were selected for operation for both groups. In the control group, we used 1ml injector to extract the vitreous body and then filled it with thermosensitive chitosan-based hydrogel. While we conducted vit- rectomy and then filled the vitreous body with thermosensitive chitosan-based hydrogel for the experimental group. After the operations, we followed up for a month to compare the intraocular pressure and the complications of the two groups of rabbits. Results: In the experi- mental group, there is no statistically significant difference between the eye pressure before operation and that after operation (P>0.05). While the eye pressure is significantly different in the control group, before and after operation(P<0.05). The incidence of complications in the control group after the operation is 44.4% (4/9), which is much higher than incidence in experimental group 22.2%(2/9). Conclusion: The operation of injecting thermosensitive chitosan-based hydrogel into vitreous body is easier to conduct, but is also more likely to cause intraocular pressure change. While, the operation of filling thermosensitive chitosan-based hydrogel after vitrectomy will not cause in- traocular pressure change, and leads to less complications, but the attention of complicated cataract should be taken.