阿伦膦酸钠与阿法骨化醇联合治疗妇女绝经后骨质疏松症的疗效

目的:探讨妇女绝经后骨质疏松症(PMO)应用阿伦膦酸钠(ALN)与阿法骨化醇联合治疗的临床效果。方法:选取我院门诊2013年1月~2015年3月收治的98例PMO患者,按照数字随机表法均分为两组。对照组:在常规钙剂基础上,给予阿法骨化醇治疗;观察组:在对照组基础上,给予ALN治疗。记录比较两组治疗前后Ward三角区、股骨颈及腰椎L2~L4骨密度(BMD)水平,治疗前后翻身、前屈后伸及自发性腰背痛视觉模拟评分法(VAS)评分,治疗前后血清骨钙素(BGP)、骨碱性磷酸酶(BALP)、Ⅰ型胶原C端肽(CTX)及抗酒石酸酸性磷酸酶5b(TRACP-5b)水平,用药期间不良反应。结果:观察组治疗后Ward三角区、股骨颈及腰椎L2~L4 BMD水平与治疗前比较,均明显改善(P0.05),且观察组改善程度更加明显(P0.05);观察组治疗后翻身、前屈后伸及自发性腰背痛VAS评分与治疗前比较,均显著降低(P0.01),且观察组改善程度更为显著(P0.01);观察组治疗后血清BGP、BALP、CTX及TRACP-5b水平与治疗前比较,均显著下降(P0.01),且观察组改善幅度更为显著(P0.01)。结论:妇女PMO应用ALN与阿法骨化醇联合治疗更能显著提高BMD水平,缓解患者疼痛症状,改善骨代谢指标,疗效切实,安全可靠,具有较高临床参考价值。

Effect of Alendronate Combined with Alpha Ossification in the Treatment of Postmenopausal Osteoporosis

Objective:To investigate the clinical effect of alendronate (ALN) combined with alpha ossification in the treatment of in postmenopausal osteoporosis(PMO).Methods:98 cases of PMO patients treated in the outpatient department in our hospital from January 2013 to March 2015 were selected and divided into two groups with the method of random number table. The control group, on the basis of conventional calcium, was given the treatment of alcohol; the observation group, on the basis of the control group, was given ALN treatment. The ward''s triangle, femoral neck and lumbar spine L2~L4 bone mineral density (BMD) level, turn, flexion and spontaneous low back pain visual simulation score(VAS), serum bone gla protein(BGP), bone alkaline phosphatase(BALP), type I collagen C telopeptide(CTX) and tartrate resistant acid phosphatase 5b(TRACP-5b) level before and after the treatment, and adverse reactions during medication were recorded and compared between the two groups.Results:In the observation group after the treatment, ward triangle area, the femoral neck and lumbar BMD L2~L4 level compared with those before the treatment, significantly improved (P<0.05), and the improvement degree of the observation group was more obvious (P<0.05); as for the patients in the observation group, flexion extension, spontaneous and turning back pain VAS scores compared with those before the treatment significantly decreased (P<0.01), and the improvement degree of the observation group was more significant (P<0.01); after the treatment, the serumlevels of BGP, BALP, CTX and TRACP-5b in the observation group significantly decreased compared with those before treatment(P<0.01), and the improvement degree of the observation group was more significant (P<0.01).Conclusion:ALN combined with alpha ossification in the treatment of the treatment of PMO can significantly improve the level of BMD, relieve patients'' pain symptoms and improve bone metabolism indicators, effectively, safely and reliably, with a high clinical reference value.