肥胖/糖尿病与肿瘤的相关性及其分子机制的研究进展

全球范围内,肥胖、糖尿病和肿瘤的发病率持续上升,已成为严重危害人类生命健康、降低人类生活质量的全球性重大公共卫生问题。近来研究发现,肥胖/糖尿病与肿瘤的关系密切,然而其分子机制尚不十分明确。目前已发现的可能的分子机制有胰岛素抵抗作用、糖代谢异常、慢性炎症反应、免疫系统失调、肥胖相关基因过度表达、癌基因与抑癌基因的异常表达、白色脂肪组织的功能紊乱等。阐明肥胖/糖尿病与肿瘤的关系及相关的分子机制,对个人和全社会都具有非常重要的意义,因此本文围绕肥胖/糖尿病与肿瘤的关系及其分子机制进行全面系统的综述。

The Correlation and Molecular Mechanisms between Obesity/Diabetes and Cancer

ABSTRACT: Worldwide, obesity, diabetes and cancer incidence is increasing continually, and have become the global serious pub- lic health issues that greatly harm people''s health and lower the life quality. Recent studies have found that obesity / diabetes is closely re- lated to tumor, but its molecular mechanism is not very clear. It has been found that the possible molecular mechanisms, such as the ac- tion of insulin resistance, abnormal glucose metabolism, chronic inflammatory reaction, immune system disorders, overexpressed obesity related genes (such as FTO and NYGGF4), oncogene and anti abnormal expression of cancer genes (such as N-myc, p53), white fat tissue endocrine function. To clarify the relationship and the molecular mechanisms between obesity/diabetes and tumor, it is important for indi- viduals and the whole society.