MAPKs信号通路在动脉粥样硬化发生发展中的调控作用

丝裂原激活蛋白激酶(mitogen-activated protein kinases,MAPKs)信号通路是生物体内重要的信号传导通路,其主要参与调控细胞的增殖、生长、分化、凋亡和炎症反应等多种生理病理过程。MAPKs信号通路在多种心血管疾病的病理过程中起着重要调控作用。动脉粥样硬化(athrosclerosis,AS)所致的各种急重症严重危害人类的健康,发病率呈逐年上升的趋势,但是动脉粥样硬化发生发展的分子机制尚不完全清楚。近年来,MAPKs信号通路在动脉粥样硬化(athrosclerosis,AS)的发生发展中的作用已成为是研究的热点。

MAPKs Signal Transduction Pathways in the Development of Athrosclerosis

ABSTRACT: Mitogen-activated protein kinase (MAPK) signal transduction pathways are ubiquitous and highly evolutionarily con- served mechanisms of eukaryotic cell regulation, controling essential processes in all eukaryotic cells, including cell proliferation, devel- opment, differentiation, apoptosis and inflammation reaction. MAPK signaling cascades likely play an important role in the pathogenesis of cardiac and vascular disease. Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of produc- tive life years worldwide, while its molecular mechanism of development is unclear. Recently, more attention is paid to its functions in the atherosclerotic development.