腔静脉滤器植入联合导管溶栓术治疗下肢深静脉血栓的疗效分析

目的:探讨腔静脉滤器植入联合导管溶栓术治疗下肢深静脉血栓患者的临床疗效及安全性。方法:回顾性分析2012年10月~2014年10月来我院住院治疗的80例下肢深静脉血栓形成患者的临床资料,根据治疗方式及溶栓途径的差异分为两组,比较两组患者治疗前后下肢周径差变化、静脉通畅率、血栓后综合征情况及治疗后并发症的发生情况。结果:治疗后,两组患者下肢平均周径均有所减少,肿胀明显缓解,静脉通畅度评分显著降低,较治疗前差异有统计学意义(P0.05);其中,观察组患者下肢消肿率更为明显,静脉通畅度更好,较对照组差异有统计学意义(P0.05)。治疗后对照组患者PTS发生例数为9例(23.68%),观察组PTS发生率更低仅为1例(2.38%),差异有统计学意义(P0.05)。两组患者治疗后均出现并发症,但发生率比较无明显统计学意义(P0.05)。结论:采用腔静脉滤器植入联合导管溶栓术治疗下肢深静脉血栓可使静脉阻塞部位尽早恢复通畅,减少瓣膜功能损害,降低PTS等并发症的发生率。

Efficacy of Vena Cava Filter Implantation Combined with Catheter Directed Thrombolysis in the Treatment of Lower Extremity Deep Venous Thrombosis

ABSTRACT Objective: To investigate the clinical efficacy and safety of intravenous cavity filter implantation combined with catheter directed thrombolysis for deep venous thrombosis patients. Methods: The clinical data of 80 cases of patients with deep vein thrombosis in our hospital from October 2012 to October 2014 were retrospectively analyzed, according to the different treatment meth- ods and therapy, the patients were divided into two groups, the lower limb circumference difference, venous patency, post thrombotic syndrome and complications were compared before and after the treatment between two groups. Results: After treatment, the average cir- cumferences and swelling of lower limb as well as venous patency score of both groups were decreased compared with those before treat- ment(P<0.05), which were more obvious in the observation group compared with those of the control group after treatment(P<0.05). After treatment, PTS occurred in 9 cases (23.68%) in the control group, while the incidence of PTS was lower in the observation group(2.38%)(P<0.05). There was no significant difference in the incidence of complications after treatment between two groups (P>0.05). Conclusion: The use of vena cava filter implantation combined with catheter directed thrombolysis could make the vein obstruction site as early as possible to restore patency, reduce the valve dysfunction and the incidence of PTS and other complications in the treatment of lower extremity deep venous thrombosis.