| VEGF-C和VEGF-D在肝内胆管癌组织中的表达与淋巴结转移的关系及临床意义 |
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| 引用本文： | 吴碧川,曾虎,张杰军,朱晋峰.VEGF-C和VEGF-D在肝内胆管癌组织中的表达与淋巴结转移的关系及临床意义[J].现代生物医学进展,2011,11(15):2910-2913. |
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| 作者姓名： | 吴碧川 曾虎 张杰军 朱晋峰 |
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| 作者单位： | 湖南师范大学附属湘东医院肝胆外科病理科,湖南醴陵,412200 |
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| 摘 要： | 目的:探讨胆管癌患者血管内皮生长因子C和D(vascular endothelial growth factor-C and-D,VEGF-C and VEGF-D)在胆管癌组织中的表达及其与肿瘤淋巴结转移的关系。方法:应用免疫组化SABC法及Real-time PCR法检测57例胆管癌组织和正常胆管组织中VEGF-C、VEGF-D蛋白及其mRNA的表达。结果:胆管癌组织VEGF-C和VEGF-D表达明显高于正常胆管组织(P<0.01),其中淋巴结转移组VEGF-C、VEGF-D的表达与淋巴结未转移组间统计学差异显著(P<0.05)。VEGF-C和VEGF-D在胆管癌组织中的表达与淋巴结转移有关(P<0.01)。结论:胆管癌细胞非摄入性高表达的VEGF-C和VEGF-D与淋巴结转移密切相关,可作为评估胆管癌患者预后的重要参考指标。
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| 关 键 词： | 胆管癌 VEGF-C VEGF-D 淋巴结转移 |
Expressions of VEGF-C and VEGF-D in Intrahepatic Cholangiocarcinoma and Its Relationship with Lymph Node Metastasis |
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| WU Bi-chuan,ZENG Hu,ZHANG Jie-jun,ZHU Jin-feng.Expressions of VEGF-C and VEGF-D in Intrahepatic Cholangiocarcinoma and Its Relationship with Lymph Node Metastasis[J].Progress in Modern Biomedicine,2011,11(15):2910-2913. |
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| Authors: | WU Bi-chuan ZENG Hu ZHANG Jie-jun ZHU Jin-feng |
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| Institution: | WU Bi-chuan,ZENG Hu,ZHANG Jie-jun,ZHU Jin-feng (The affiliated Xiangdong hospital of Hunan Normal University,412200,China) |
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| Abstract: | Objective:To explore the expression of vascular endothelial growth factor C and D in ICC and its relationship with tumor angiogenesis,lymph node metastasis.Methods:Immunohistochemistry(SABC) and Real-time PCR were used to detect the protein expression and mRNA level of VEGF-C and VEGF-D in 57 samples of ICC tissue and normal gastric tissue.Results:The positive expression rate of VEGF-C and VEGF-D in ICC tissue was significantly higher than in normal gastric tissues(P<0.01).VEGF-C, VEGF-D expression in ICC g... |
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| Keywords: | Intrahepatic Cholangiocarcinoma Vascular Endothelial Growth Factor-C Vascular Endothelial Growth Factor- D Lymph Node Metastases |
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